Fluconazole is noted, among azoles, for its good penetration. Its water solubility allows not only for i.v. administration but also accounts for good bioavailability by the route of administration. Drug-drug interactions are less common with fluconazole because it interacts less with the metabolizing system. It is the drug of choice for treating . I.V. fluconazole has been show to be equivalent to in management of candidemia in the ICU setting, assuming that the patient has normal white cell blood counts. Oral high-dose fluconazole may be often be an effective replacement for amphotericin B route of administration for treating .