Practice Exam I: Adrenergic Pharmacology
Click on the correct answer.
Very potent beta adrenergic receptor agonists with minimal effects on alpha adrenergic receptors:
- propranolol (Inderal) propranolol (Inderal)
- isoproterenol (Isuprel)
- epinephrine
- yohimbine (Yocon)
- phentolamine (Regitine)
Most likely to produce a reflex-mediated bradycardia:
- low-dose epinephrine
- isoproterenol (Isuprel)
- mecamylamine (Inversine)
- methoxamine (Vasoxyl)
- atropine
Sympathomimetic due to inhibition of transmitter uptake at noradrenergic synapses:
- cocaine
- ephedrine
- dobutamine (Dobutrex)
- epinephrine
- yohimbine (Yocon)
Beta-2 selective agonist-- typically administered by aerosol for asthma management:
- epinephrine
- isoproterenol (Isuprel)
- cromolyn sodium (Intal)
- beclomethasone (Banceril)
- albuterol (Ventolin,Proventil)
Useful in management of hypotensive states:low-dose increases renal blood flow:
- dobutamine (Dobutrex)
- isoproterenol (Isuprel)
- dopamine (Intropin)
- phenylephrine (Neo-Synephrine)
- norepinephrine (Levophed)
Used to suppress premature labor:
- isoproterenol (Isuprel)
- losartin (Cozaar)
- ritodrine (Yutopar)
- phenylephrine (Neo-Synephrine)
- clonidine (Catapres)
Produces epinephrine reversal, converting a pressor response to a deep pressor response:
- losartin (Cozaar)
- propranolol (Inderal)
- metoprolol (Lopressor)
- phentolamine (Regitine)
- clonidine (Catapres)
Choose the incorrect statement concerning metabolic effects of sympathomimetic agents
- Activation of beta receptors in fat cells increase lipolysis.
- Alpha -- 2 adrenergic receptors inhibit lipolysis
- Hepatic catecholamine effects our mediated mainly by beta adrenergic receptor activation
- At high concentrations, catecholamines may induce a metabolic acidosis
- Sympathomimetic drugs increase extracellular potassium
Effects of sympathomimetic agents on the gastrointestinal tract:
- alpha -adrenergic receptor activation relaxes gastrointestinal smooth muscle
- beta-adrenergic receptor activation relaxes gastrointestinal smooth muscle
- alpha-2 agonists act indirectly by reducing acetylcholine release (presynaptic effect)
- A & B
- A,B & C
Catecholamine effects: choose the incorrect match(es):
- Gs -- stimulatory G. protein of adenylyl cyclase
- Gi -- inhibitory G protein of adenylyl cyclase
- Gq -- protein coupling between beta-receptors and phospholipase C
- A & B
- A, B & C
Catecholamine desensitization
- receptor sequestration
- receptor down regulation
- receptor phosphorylation
- A & B only
- A, B & C
Correct receptor type: tissues -- actions
- alpha 1: heart: positive inotropic
- alpha 1: pupillary dilator muscle: miosis (pupillary contraction)
- alpha 2:cholinergic nerve terminals: facilitate transmitter release
- beta 1: heart: decrease forests of contraction
- beta 2:human liver: inhibits glycogenolysis
Correct receptor type: tissues: actions
- alpha 1:most innervated vascular smooth muscle: contraction
- alpha 2:platelets: aggregation
- beta 2:uterine smooth muscle: smooth muscle relaxation
- A & C
- A, B & C
Effectively blocks reflex bradycardia following phenylephrine administration:
- prazosin (Minipress)
- propranolol (Inderal)
- mecamylamine (Inversine)
- A & C
- A, B & C
Rate-determining enzyme reaction in catecholamine biosynthesis
- phenylethanolamine N-methyltransferase
- dopa decarboxylase
- tyrosine hydroxylase
- dopamine beta-hydroxylase
- catechol-O-methyltransferase
Adrenergic Pharmacology; Adrenergic Agonists; Asthma Management
|