Medical Pharmacology Practice Questions: Autonomic Pharmacology

Clinical applications of beta-adrenergic antagonists:
1. management of coronary vascular disease
2. treatment of arrhythmias
3. treatment of hypertension
4. all the above
A non-selective beta-adrenergic receptor blocker:
1. metoprolol (Lopressor)
2. atenolol (Tenormin)
3. timolol (Blocadren)
4. esmolol (Brevibloc)
Beta-adrenergic receptor blockers: effects on the heart --
1. increase heart rate
2. increased AV nodal refractory period
3. increased contractility
4. increased myocardial oxygen demand
5. increased phase 4 depolarization
Beta-adrenergic receptor blockers are usually effective in reducing blood pressure in both " high-renin" and "low-renin" patients:
1. true
2. false
Most likely to cause dangerous bronchiolar constriction in asthmatic patients or patients with COPD
1. metoprolol (Lopressor)
2. propranolol (Inderal)l
3. esmolol (Brevibloc)
4. atenolol (Tenormin)
Mechanism(s) for propranolol-decreased amide local anesthetic clearance:
1. decreased hepatic blood flow
2. inhibition of hepatic metabolism of local anesthetic
3. both
4. neither
Effect of propranolol (chronic administration) on pulmonary first-pass fentanyl (Sublimaze) uptake
1. significant reduction
2. significant enhancement
The major exception to the rule that additive myocardial depression between anesthetics and beta-adrenergic antagonists is not excessive:
1. metoprolol (Lopressor)
2. propranolol (Inderal)
3. esmolol (Brevibloc)
4. timolol (Blocadren)
5. nadolol (Corgard)
Bradycardia hypotension, refractory to atropine, may occur during anesthesia in pediatric and adult patients receiving this beta adrenergic receptor antagonist:
1. nadolol (Corgard)
2. propranolol (Inderal)
3. esmolol (Brevibloc)
4. timolol (Blocadren)
Greatest additive cardiovascular effects with inhaled anesthetics in the presence of beta-adrenergic receptor blockade:
1. enflurane (Ethrane)
2. halothane (Fluothane)
3. isoflurane (Forane)
Preferred beta-blocking agent to prevent systolic blood pressure increases associated with direct laryngoscopy in tracheal intubation:
1. IV propranolol (Inderal)
2. IV labetalol (Trandate, Normodyne)
3. IV esmolol (Brevibloc)
4. IV timolol (Blocadren)
5. IV nadolol (Corgard)
Beta-blocker having special benefits for patients undergoing noncardiac surgery but having significant underlying coronary artery disease-- given IV perioperatively and orally during remainder of hospital stay.
1. esmolol (Brevibloc)
2. atenolol (Tenormin)
3. propranolol (Inderal)
4. nadolol