Medical Pharmacology Clinical Case: Management of Pilocarpine Toxicity

Medical Pharmacology Clinical Case: Pilocarpine Intoxication

An 18 yr. old man attempts suicide by drinking two small bottles of liquid pilocarpine (Pilocar, 1%) eyedrops, about 8 ml, followed by injecting one ml of the same substance subcutaneously. Shortly thereafter, a few minutes, he began vomiting. At this time he was found by a friend and taken to the emergency department of a nearby hospital.

An 18 yr. old man attempts suicide by drinking two small bottles of liquid pilocarpine (Pilocar) (1%) eyedrops -- about 8 ml -- followed by injecting one ml of the same substance subcutaneously. Shortly thereafter (a few minutes), he began vomiting. At this time he was found by a friend and taken to the emergency department of nearby hospital.
How would this systemic pilocarpine dosage affect the eye?
How would the systemic pilocarpine (Pilocar) dosage affect airway?
How would the systemic pilocarpine (Pilocar) dosage affect bowel sounds?
How would the systemic pilocarpine (Pilocar) dosage affect the GU tract?
If the pilocarpine (Pilocar) caused a significant fall in BP, what would be the most likely effect on heart rate?
How would the systemic pilocarpine (Pilocar) dosage affect sweating, salivation, lactrimation?
What would be the appropriate pharmacological treatment for this patient?