Medical Pharmacology Practice Questions: Cholinergic Pharmacology

General clinical uses: anticholinesterases
1. antagonist-assisted reversal of neuromuscular blockade produced by nondepolarizing neuromuscular-blocking drugs
2. myasthenia gravis management
3. glaucoma treatment
4. treatment of paralytic ileus and urinary bladder atony
5. all of the above
Drugs used for antagonist-assisted neuromuscular-blockade reversal
1. acetylcholine
2. physostigmine (Antilirium)
3. DFP
4. edrophonium (Tensilon)
5. all of the above
Determination of the recovery rates from neuromuscular-blockade when antagonist-assisted reversal is used:
1. spontaneous recovery rate from the blocking drug
2. activity of the pharmacologic antagonist (anticholinesterase drug)
3. both (sum of A plus B)
4. difference (A- B)
When our anticholinesterase agents usually administered to enhance neuromuscular blockade reversal?
1. before the neuromuscular-blocking drug is given
2. while the neuromuscular-blocking drug is being infused
3. during the spontaneous neuromuscular-blockade recovery, following cessation of neuromuscular-blocking administration
Pharmacologic antagonism (anticholinesterase drugs) would likely be more effective for which type of neuromuscular blocking drug?
1. short-or intermediate-acting neuromuscular-blocking drugs
2. long-acting nondepolarizing neuromuscular-blockade
3. equally effective
Rationale for using muscarinic antagonists in pharmacologic (anticholinesterase-mediated) reversal of neuromuscular-blockade:
1. increases acetylcholine concentration that neuromuscular junctions
2. inhibits acetylcholinesterase
3. minimizes muscarinic receptor-mediated effects of anticholinesterase drugs
which antimuscarinic agent might be used in combination with an anticholinesterase when desiring reversal of neuromuscular-blockade and opioid-based maintenance anesthesia has been used:
1. edrophonium (Tensilon)
2. high-dose atropine (10-15 ug/kg)
3. neostigmine (Prostigmin)
More effective in reversing deep neuromuscular-blockade produced by continuous atracurium (Tracrium), vecuronium (Norcuron), or pancuronium (Pavulon) infusions
1. edrophonium (Tensilon)
2. neostigmine (Prostigmin)
3. both are equally effective
Factor(s) that may prevent or inhibit anticholinesterase-mediated antagonism of neuromuscular-blockade:
1. hyperthermia
2. respiratory alkalosis
3. hyperkalemia
4. certain antibiotics
5. all of the above
Reversal of phase II block (following prolonged repeated succinylcholine (Anectine)) in patients with normal plasma cholinesterase:
1. edrophonium (Tensilon)
2. neostigmine (Prostigmin)
3. both
4. neither
Reversal of phase II block (following prolonged or repeated succinylcholine (Anectine) administration) in patients with atypical plasma cholinesterase:
1. reliable, assisted neuromuscular blockade reversal using edrophonium (Tensilon) or neostigmine (Prostigmin)
2. unreliable, assisted neuromuscular blockade reversal using edrophonium (Tensilon) or neostigmine (Prostigmin)
Intrathecal neostigmine (Prostigmin) produces postoperative analgesia without respiratory depression:
1. true
2. false