Medical Pharmacology:
Autonomic Pharmacology Practice Questions
Choose the correct answer for each question.
Probably the neurotransmitter in sensory afferents
- acetylcholine
- bradykinin
- substance P
- glycine
- norepinephrine
Autonomic: Sympathetic
- craniosacral
- thoracolumbar
Preganglionic fibers terminating on adrenal medullary chromaffin cells release:
- norepinephrine
- epinephrine
- acetylcholine
- dopamine
- substance P
Primary receptor type at autonomic ganglia:
- adrenergic: beta 1
- adrenergic: beta 2
- cholinergic: muscarinic
- cholinergic: nicotinic
- dopaminergic: D. 1
Vesicular protein important in docking with the presynaptic membrane:
- neurexin
- syntaxin
- saxitonin
- synaptobrevin
Rate-limiting step in acetylcholine synthesis:
- choline acetyltransferase activity
- vesicular protein synthesis
- choline uptake
- acetylcholinesterase activity
- availability of acetate
Inhibits choline transport into cholinergic vesicles
- bretylium
- vesamicol
- reserpine
- atropine
Influx of this ion promotes fusion between axoplasmic membrane and nearby vesicles.
- sodium
- potassium
- calcium
- chloride
Clostridium toxins:
- inhibit acetylcholinesterase
- prevent reuptake of choline
- inhibit vesicular acetylcholine release
- prevent calcium influx
Denervation supersensitivity in skeletal muscle is mainly due to:
- increase in receptor affinity
- no increase in the receptor number
- proliferation of receptors
- increase in G.-protein coupling efficiency
- increase in acetylcholine release
Enzyme responsible for acetylcholine synthesis:
- acetylcholinesterase
- choline acetyltransferase
Cholinergic receptor type that mediates the decrease in heart rate by activating potassium channels:
- M1-- muscarinic
- M2-muscarinic
- M3-muscarinic
- nicotinic
Effect of atropine on the heart:
- increased rate
- decreased rate
Essential cofactor for the enzyme dopamine beta-hydroxylase:
- pyridoxyl phosphate
- ascorbate
- tetrahydrobiopterin
- glycine
Phosphorylation of this enzyme is most likely to have an effect on catecholamine biosynthesis:
- phenylethanolamine N-methyltransferase
- dopamine beta-hydroxylase
- tyrosine hydroxylase
- dopa decarboxylase
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