Medical Pharmacology Practice Questions: Autonomic Pharmacology

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Sympathetic nervous system anatomy and properties:
1. gangionic neurotransmitter: acetylcholine
2. generalized response upond sympathetic stimulation
3. thoraco-lumbar origin for preganglionic cell bodies
4. all of the above
Comparing autonomic and somatic nerves:
1. somatic nerves, like autonomic nerves contain ganglia.
2. Most of the fibers in the vagus nerve ar sensory
3. denervated smooth muscle show spontaneous activity
4. motor nerves are typically unmyelinated.
Major anatomical site for integration of autonomic information:
1. cerebellum
2. sensory cortex
3. hypothalamus
4. spinal cord--dorsal horn
Division of the autonomic nervous system associated with diffuse autonomic responses.
1. sympathetic
2. parasympathetic
3. both
4. neither
Activation of the sympathetic nervous system will caus which change in the skeletal muscle versus cutaneous vascular beds.
1. vasoconstriction, vasoconstriction
2. vasodilatation, vasodilatation
3. vasodilatation, vasoconstriction
4. vasoconstriction, vasodilation
Adrenergic receptor type(s) mediating pupillary dilation
1. beta-2
2. alpha-1
3. muscarinic
4. serotonergic
Cholinergic receptor type that mediates vasodilation following low-dose i.v. acetylcholine administration:
1. nicotinic
2. muscarinic
3. nitric oxide receptor
4. substance P receptor
"True" acetylcholinesterase is found in:
1. glia
2. liver
3. erythrocytes
4. plasma
Catalyzes rate-limiting step in catecholamine biosynthesis:
1. DOPA decarboxylase
2. phenylethanolamine N-methyl transferase
3. tyrosine hydroxylase
4. dopamine-beta-hydroxylase
Inhibited by drugs such as phenelzine or tranylcypromine;
1. COMT (catechol-O-methyl transferase)
2. MAO (monoamine oxidase)
3. choline acetyltransferase
4. reuptake-I inhibitor
Concentation increased by epinephrine:
1. blood free fatty acids
2. blood glucose
3. skeletal muscle glycogen
4. A & B
Due to receptor specificity, catecholamine LEAST likely to produce bronchiolar smooth muscle relaxation:
1. epinephrine
2. terbutaline (Brethine)
3. phenylephrine
4. phentolamine (Regitine)
Alpha adrenergic receptor blocker
1. phentolamine (Regitine)
2. phenoxybenzamine (Dibenzyline)
3. terbutaline (Brethine)
4. A & B
Covalent inhibitor of acetylcholinesterse:
1. edrophonium (Tensilon)
2. diisopropylphosphate (DFP)
3. atropine
4. muscarine
Alpha-adenergic receptor agonist:
1. terbutaline (Brethine)
2. atropine
3. methoxamine (Vasoxyl)
4. isoproterenol (Isuprel)
Parasympathetic direct cardiac effects:
1. decrease heart rate; increase contractility
2. increase heart rate; decrease contractility
3. decrease heart rate; decrease contractility
4. increase AV nodal conduction velocity
Choline ester substrate for acetylcholinesterase:
1. carbachol
2. methacholine (Provocholine)
3. both
4. neither
Alkaloid agonist acting at muscarinic, cholinergic receptors:
1. DFP
2. pilocarpine (Pilocar)
3. physostigmine (Antilirium)
4. ipratropium (Atrovent)
Effective in treating both organophosphate and muscarine intoxication:
1. nicotine
2. echothiophate (Phospholine)
3. atropine
4. pilocarpine (Pilocar)
Cholinergic activity on stomach acid secretion
1. increased
2. decreased
3. no changed
4. one of the others is right