Medical Pharmacology: Antihypertensive Drugs Practice
Questions
Click on the correct answer.
This antihypertensive drug is contraindicated in patients with bilateral renal artery stenosis:
clonidine (Catapres)
terazosin (Hytrin)
nifedipine (Procardia, Adalat)
captopril (Capoten)
metoprolol (Lopressor)
Antihypertensive drug typically used in patients with severe hypertension and renal insufficiency; this agent produces significant fluid retention and hypertrichosis.
hydralazine (Apresoline)
methyldopa (Aldomet)
minoxidil (Loniten)
nitroprusside sodium (Nipride)
diltiazem (Cardiazem)
The drug of choice in management of hypertensive crisis when continuously variable IV infusion is required.
lisinopril (Prinvivil, Zestril)
diazoxide (Hyperstat)
nifedipine (Procardia, Adalat)
nitroprusside sodium (Nipride)
metoprolol (Lopressor)
A drug-induced lupus-like syndrome is associated with this antihypertensive drug
minoxidil (Loniten)
hydralazine (Apresoline)
diazoxide (Hyperstat)
nitroprusside sodium (Nipride)
acebutolol (Sectral)
Tachycardia due to hydralazine administration would be blocked by:
bumetanide (Bumex)
fosinopril (Monopril)
mecamylamine (Inversine)
nifedipine (Procardia, Adalat)
minoxidil (Loniten)
A diabetic patient is prescribed a new medication to control mild hypertension. The patient then becomes less aware of hypoglycemic symptoms. The antihypertensive drug was most probably:
phentolamine (Regitine)
atenolol (Tenormin)
enalapril (Vasotec) and
hydralazine (Apresoline)
prazosin (Minipress)
Which drug would be least likely used in the initial pharmacological treatment of mild hypertension?
amlodipine (Norvasc)
metoprolol (Lopressor)
enalapril (Vasotec)
minoxidil (Loniten)
chlorothiazide (Diuril)
Which antihypertensive drug would be contraindicated if the patient were taking tranylcypromine (Parnate)?
hydrochlorothiazide (HCTZ, Esidrix, HydroDIURIL)
diltiazem (Cardiazem)
guanethidine (Ismelin)
lisinopril (Prinvivil, Zestril)
labetalol (Trandate, Normodyne)
Which drug would block the antihypertensive efficacy of guanadrel (Hylorel)?
buspirone (BuSpar)
lorazepam (Ativan)
imipramine (Tofranil)
propranolol (Inderal)
chlorothiazide (Diuril)
Lisinopril belongs to which class of antihypertensive drugs?
centrally-acting sympatholytic
beta-adrenoceptor antagonist
angiotensin II receptor antagonist
beta-adrenoceptor agonist
angiotensin II converting enzyme inhibitor
Most likely to be used for initial drug management of moderate hypertension
guanethidine (Ismelin)
nitroprusside sodium (Nipride)
minoxidil (Loniten)
nifedipine (Procardia, Adalat)
hydralazine (Apresoline)
Antihypertensive agents -- side effect profile includes impaired glucose tolerance, hypokalemia, increased serum lipids and increased renin secretion:
methyldopa (Aldomet)
chlorothiazide (Diuril)
nifedipine (Procardia, Adalat)
nitroprusside sodium (Nipride)
diazoxide (Hyperstat)
Effects of hydralazine (Apresoline):
increased renin levels
lupus-like syndrome
reflex bradycardia
hypertensive response if patient ingests food rich in tyramine
all of the above
Mechanisms by which blood-pressure may be reduced:
reduced cardiac output
increased vagus nerve activity
decreased central sympathetic outflow
reduced angiotensin II levels
all the above
Orthostatic hypotension:
minoxidil (Loniten)
imipramine (Tofranil)
hydralazine (Apresoline)
methyldopa (Aldomet)
all of the above
Antihypertensive drug least likely to cause orthostatic hypotension:
minoxidil (Loniten)
enalapril (Vasotec)
guanethidine (Ismelin)
hydralazine (Apresoline)
terazosin (Hytrin)
Vascular smooth muscle relaxation by means of calcium channel blockade:
hydralazine (Apresoline)
nitroprusside sodium (Nipride)
nifedipine (Procardia, Adalat)
captopril (Capoten)
phentolamine (Regitine)
Protects against tachycardia caused by minoxidil (Loniten) administration:
prazosin (Minipress)
diltiazem (Cardiazem)
metoprolol (Lopressor)
losartin (Cozaar)
methyldopa (Aldomet)
Mechanism of antihypertensive action:inhibition of peptidyl dipeptidase
metoprolol (Lopressor)
verapamil (Isoptin, Calan)
lisinopril (Prinvivil, Zestril)
diazoxide (Hyperstat)
Antihypertensive agent that can produce a positive Coombs' test
clonidine (Catapres)
guanabenz (Wytensin)
guanfacine (Tenex)
methyldopa (Aldomet)
all the above
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