Medical Pharmacology Test Questions: Vasodilators

Antianginal agent most likely to cause methemoglobinemia:
1. isosorbide dinitrate (Isordil, Sorbitrate)
2. propranolol (Inderal)
3. nitroglycerin
4. amyl nitrite
5. metoprolol (Lopressor)
Vasodilation by direct action on vascular smooth muscle
1. minoxidil (Loniten)
2. hydralazine (Apresoline)
3. nitroglycerin
4. all the above
Side effect least likely to be seen with nitroglycerin:
1. hypertension
2. headache
3. dizziness
4. palpitations
Antianginal agents administered by inhalation:
1. nitroglycerin
2. phentolamine (Regitine)
3. amyl nitrite
4. metoprolol (Lopressor)
5. captopril (Capoten)
Antianginal agent which decreases myocardial contractility (negative inotropism)
1. amrinone (Inocor)
2. nitroglycerin
3. amyl nitrite
4. metoprolol (Lopressor)
5. phentolamine (Regitine)
Physiological properties of nitrates:
1. cause vasodilation by releasing potassium which activates guanylyl cyclase
2. primarily cause venular smooth muscle relaxation
3. act primarily through dilation of coronary arteries
4. increased myocardial preloaded
5. increased myocardial wall tension
Calcium channel blocker -- most effective vasodilator:
1. verapamil (Isoptin, Calan)
2. nifedipine (Procardia, Adalat)
3. nicardipine (Cardene)
4. diltiazem (Cardiazem)
5. nimodipine (Nimotop)
Calcium channel blocker most likely to decrease contractility, reduce sinoatrial nodal impulse generation, and slow AV nodal conduction.
1. diltiazem (Cardiazem)
2. nicardipine (Cardene)
3. nifedipine (Procardia, Adalat)
4. nimodipine (Nimotop)
5. verapamil (Isoptin, Calan)
Effective in management of variant (Prinzmetal's) angina:
1. propranolol (Inderal)
2. nitroglycerin
3. diltiazem (Cardiazem)
4. A & C
5. B & C
Blocks tachycardia resulting from nitroglycerin administration
1. atropine
2. phenoxybenzamine (Dibenzyline)
3. propranolol (Inderal)