Medical Pharmacology: Depression and Antidepressant Medications

Which one of the following atypical class antidepressant drugs is most likely associated with the risk of seizure?
1. Mirtazapine (Remeron)
2. Nefazodone (Serzone)
3. Trazodone (Desyrel)
4. Buproprion (Wellbutrin)
Which one of the following atypical-type antidepressant drugs is most likely associated with agitation?
1. Fluvoxamine (Luvox)
2. Buproprion (Wellbutrin)
3. Atomoxetine (Strattera)
4. Trazodone (Desyrel)
Which one of the following atypical-type antidepressant drugs is associated with both adverse GI and adverse sexual effects?
1. Fluvoxamine (Luvox)
2. Buproprion (Wellbutrin)
3. Nefazodone (Serzone)
4. Mirtazapine (Remeron)
Which one of the following atypical-type antidepressant drugs is LEAST LIKELY sedating?
1. Mirtazapine (Remeron)
2. Nefazodone (Serzone)
3. Buproprion (Wellbutrin)
4. Trazodone (Desyrel)
All of the following antidepressant medications are classified as monoamine oxidase inhibitors (MAOI) EXCEPT:
1. Tranylcypromine (Parnate)
2. Selegiline (Eldepryl)
3. Duloxetine (Cymbalta)
4. Phenelzine (Nardil)
Monoamine oxidase inhibitor (MAOI)-type antidepressants may exhibit side effects associated with which one/ones of the following mechanism(s)?
1. Muscarinic/cholinergic receptor blockade
2. Alpha1-adrenergic receptor blockade
3. Both
4. Neither
Choose which one of the following side effects associated with monoamine oxidase inhibitor administration is the most serious?
1. Inducing mania in patients with bipolar disorder
2. Acute hypertensive crisis
3. Ataxia
4. Hepatotoxicity
Coadministration of monoamine oxidase inhibitors (MAOIs) with which one/ones of the following may induce a central serotonin syndrome?
1. L-tryptophan
2. Citalopram (Celexa)
3. Both
4. Neither
Concerning the central serotonin syndrome which may occur following coadministration of MAOIs with SSRIs, the syndrome is typically mild in nature and usually resolves within 24 hours following drug discontinuation.
1. True
2. False
Which one of the following antidepressant agents is most likely to affect the heart the same way as class I antiarrhythmic agents e.g. quinidine or procainamide?
1. Venlafaxine (Effexor)
2. Sertraline (Zoloft)
3. Trazodone (Desyrel)
4. Duloxetine (Cymbalta)
Which one(s) of the following antidepressant agents is/are most likely to affect the heart the same way as class I antiarrhythmic agents e.g. quinidine or procainamide?
1. Imipramine (Tofranil)
2. Doxepin (Sinequan)
3. Amitriptyline (Elavil)
4. Clomipramine (Anafranil)
5. All of the above
Antidepressant drugs are mainly metabolized in the liver with mechanisms that include demethylation, hydroxylation, and glucuronide conjugation.
1. True
2. False
Refractory depression might be effectively treated by using a combination of the noradrenergic-type antidepressant such as desipramine in combination with an SSRI such as fluoxetine.
1. True
2. .
Venlafaxine (Effexor), classified as a mixed norepinephrine and serotonin reuptake inhibitor,when administered at dosages greater than 300 mg/day can produce a prominent hypotensive response, similar to orthostatic hypotension responses.
1. True
2. False
The first demethylation step in the metabolism of imipramine produces the clinically active antidepressant agent desipramine.
1. True
2. False