Medical Pharmacology: General Anesthesia Practice Questions

Factors determining anesthetic partial pressure in arterial blood:
1. anesthetic concentration in the inspired air
2. pulmonary ventilation
3. transfer of gas from blood to body tissues
4. A & C
5. A, B & C
Depth of anesthesia primarily depends on:
1. patient age
2. Rate of hepatic anesthetic metabolism
3. anesthetic partial pressure (tension) in brain
4. rate of transfer of gas from the blood to alveoli
5. rate of redistribution of the anesthetic from the brain to other tissues
Fastest rate of rise of arterial gas tension (as% of inspired tension):
1. halothane (Fluothane)
2. ether
3. nitrous oxide
4. isoflurane (Forane)
5. all are equal
Differences between anesthetics in terms of rate of rise of arterial gas tension are primarily due to:
1. different rates of anesthetic metabolism
2. differential excretion rates
3. anesthetic physical properties, e.g. solubility
Relationship between the rate of rise of anesthetic concentration in the blood and rate of rise of anesthetic concentration in the brain.
1. direct
2. inverse
Pulmonary ventilation --factor that accelerates attainment of brain anesthetic concentration
1. respiratory depression
2. overventilation during induction
3. both
4. neither
Anesthetic solubility in the blood:
1. The more soluble in age and is in the blood the less must be dissolved to raise its partial pressure (tension)
2. Inhalational agent solubility is a relatively unimportant factor in determining the speed of induction recovery
3. Induction times may be prolonged with methoxyflurane because of its high solubility
Pulmonary blood flow & gas transfer from alveoli to blood
1. Pulmonary blood flow is inversely related to cardiac output
2. With higher pulmonary flow, there is an initial relative decrease in the rate of rise of anesthetic tension
3. both
4. neither
Partial pressure in arterial and mixed venous blood & gas transfer from alveoli to blood:the amount of dissolved anesthetic and mixed venous blood returning to the lung has no effect on the rate of transfer anesthetic gas into the blood
1. true
2. false
Factors that determine how quickly anesthetics pass from the inspired gas to the blood:
1. Anesthetic solubility in the blood
2. Partial pressures in arterial and mixed venous blood
3. Pulmonary blood flow
4. A & C
5. A, B & C
Factors affecting transport of anesthetic from arterial blood to tissues:
1. rate of delivery of anesthetic to tissue
2. solubility of the gas in tissues
3. difference impartial pressures between arterial blood and tissue
4. A & C
5. A, B & C