Medical Pharmacology Practice Questions: Opioid Pharmacology

Physiological effect NOT typically associated with opioids:
1. constipation
2. constriction of biliary smooth muscle
3. enhanced renal function
4. limited direct cardiovascular effects
5. may prolong labor
Mixed agonist-antagonist:
1. naloxone (Narcan)
2. naltrexone (ReVia)
3. hydromorphone (Dilaudid)
4. nalbuphine (Nubain)
5. diphenoxylate (Lomotil)
Used in treatment diarrhea:
1. difenoxin
2. diphenoxylate (Lomotil)
3. loperamide (Imodium)
4. B & C
5. A,B & C
Contraindications/caution for opioid use:
1. patients with Addison's disease
2. patients with impaired pulmonary function
3. patients with head injury
4. B & C
5. A, B & C
Useful drug(s) for opioid detoxification and maintenance of chronic relapsing heroin addict:
1. methadone (Dolophine)
2. levomethadyl acetate
3. propoxyphene (Darvon)
4. A & B
5. A, B & C
Effective antitussive(s)
1. codeine
2. morphine
3. dextromethorphan
4. oxycodone (Roxicodone)
5. all the above
Opioid antagonist with shortest duration of action:
1. naloxone (Narcan)
2. nalmefene (Revex)
3. naltrexone (ReVia)
4. all about equal duration of action
5. these agents are not opioid antagonists
Routes of opioid agonist administration:
1. transdermal
2. patient-controlled analgesia (PCA)
3. intranasal
4. A & B
5. A, B & C
Signs and symptoms of acute opioid withdrawal (abstinence syndrome)
1. yawning
2. lacrimation
3. hyperventilation
4. diarrhea
5. all the above
In obstetrical applications:opioid less likely to produce respiratory depression in the newborn
1. meperidine (Demerol)
2. morphine