Medical Pharmacology: Antipsychotic Drug Practice Questions

Butyrophenone antipsychotic:
1. thioridazine (Mellaril)
2. chlorpromazine (Thorazine)
3. thiothixene (Navane)
4. haloperidol (Haldol)
5. fluphenazine (Prolixin)
An example of an "atypical" antipsychotic agent:
1. thioridazine (Mellaril)
2. thiothixene (Navane)
3. risperidone (Risperdal)
4. chlorpromazine (Thorazine)
5. none of the above
Site(s) of chlorpromazine (Thorazine) receptor blockade:
1. alpha adrenergic receptor
2. muscarinic cholinergic receptor
3. H1 histaminic receptor
4. serotonin -- 5-HT2 receptor
5. all of the above
Associated with a LOW clinical potency but HIGH degree of sedation:
1. thiothixene (Navane)
2. haloperidol (Haldol)
3. chlorpromazine (Thorazine)
4. olanzapine (Zyprexa)
Antipsychotic drug with least extrapyramidal toxicity:
1. fluphenazine (Prolixin)
2. haloperidol (Haldol)
3. clozapine (Clozaril)
4. thiothixene (Navane)
5. chlorpromazine (Thorazine)
Antipsychotic drug:least hypotensive effect:
1. chlorpromazine (Thorazine)
2. thiothixene (Navane)
3. clozapine (Clozaril)
4. olanzapine (Zyprexa)
5. all about equal in hypotensive action
Psychological effect of antipsychotic drugs taken by nonpsychotic individuals:
1. pleasant, euphoric; associated with increased psychomotor performance
2. unpleasant, associated with decreased psychomotor performance
Antipsychotic endocrine effect(s):
1. false-positive pregnancy tests
2. increased libido in women
3. decreased libido in men
4. amenorrhea-galactorrhea
5. all the above
Least likely to cause an increase in prolactin:
1. chlorpromazine (Thorazine)
2. haloperidol (Haldol)
3. perphenazine (Trilafon)
4. olanzapine (Zyprexa)
5. thiothixene (Navane)
Cardiovascular effects of "high-dose" (low-potency) phenothiazines:
1. hypertension
2. increased peripheral resistance
3. increased stroke volume
4. shortening of the Q-T interval
5. none of the above
Blockade of this receptor system most likely associated with akisthisia side effect of antipsychotic treatment:
1. muscarinic cholinergic
2. alpha adrenergic
3. dopamine
4. serotonin
5. GABA
Toxic-confusion states due to antipsychotic medication associated with effects on this receptor system
1. alpha-adrenergic
2. dopamine
3. muscarinic cholinergic
4. serotonergic
5. none-of the above
Antipsychotic drug most likely to induce agranulocytosis (around 2% frequency)
1. olanzapine (Zyprexa)
2. risperidone (Risperdal)
3. pimozide (Orap)
4. clozapine
Neurological adverse effect associated with antipsychotic drug use: occurs late in therapy
1. Parkinson's syndrome
2. akisthisia
3. acute dystonic reactions
4. tardive dyskinesia
5. all of the above
Reasonable pharmacological step(s) to treat tardive dyskinesia:
1. increase antipsychotic drug dose
2. add a tricyclic antidepressants to the drug regimen
3. add benztropine (Cogentin)
4. start high-dose diazepam (30-40 milligrams per day)
5. no pharmacological intervention is helpful after tardive dyskinesia is induced by antipsychotic treatment
Ocular complication of antipsychotic drug treatment: causes retinal deposits; resembles an advance cases, retinitis pigmentosa
1. haloperidol (Haldol)
2. olanzapine (Zyprexa)
3. risperidone (Risperdal)
4. thioridazine (Mellaril)
5. all the above