Anticoagulant Drug Pharmacology

Not factor VIII, but increases factor VIII activity in patients with mild hemophilia A:
1. cryoprecipitate
2. tranexamic acid
3. desmopressin acetate
4. urokinase
5. aspirin
Complex of purified human plasminogen and bacterial streptokinase
1. alteplase
2. reteplase
3. anistreplase
4. dicumarol
5. protamine sulfate
Most likely to preferentially activate plasminogen bound to fibrin
1. streptokinase
2. alteplase
3. urokinase
4. anistreplase
5. all the above
Clinical indications for fibrinolytic drugs:
1. some acute myocardial infarctions
2. ascending thrombophlebitis (iliofemoral vein)
3. some cases of multiple pulmonary emboli
4. A & B
5. A, B & C
Increases prothrombin time:
1. high-dose aspirin
2. phenobarbital
3. cholestyramine
4. rifampin
5. all of the above
Bleeding from warfarin may be reversed by:
1. vitamin K
2. factor I concentrate
3. both
4. neither
Aspirin irreversibly inhibits this enzyme, preventing thromboxane A2 synthesis.
1. adenylyl cyclase
2. guanylyl cyclase
3. adenosine deaminase
4. cyclooxygenase
5. streptokinase
Approved for prevention of the venous thrombosis after hip replacement surgery:
1. dalteparin
2. danaproid
3. enoxaparin
4. all of the above
Generated within the platelet -- interacts with membrane receptors:
1. collagen
2. thrombin
3. thromboxane A2
4. ADP
5. all of the above
Blocks GPIIb/IIIa platelet receptors:
1. thromboxane A2
2. aspirin
3. abciximab
4. ADP
5. streptokinase