Medical Pharmacology: Ergot Alkaloid Pharmacology

Ergot alkaloids act on which one(s) of the following receptor types:
1. serotonin
2. alpha-adrenergic
3. beta adrenergic
4. A & B
5. A, B & C
Ergot alkaloid with most prominent effects at dopamine receptor sites:
1. ergonovine
2. ergotamine
3. bromocriptine (Parlodel)
4. methysergide (Sansert)
5. all the above
An example of an amine ergot alkaloid:
1. bromocriptine (Parlodel)
2. ergotamine
3. alpha-ergocryptine
4. ergonovine
Very high selectivity for pituitary dopamine receptors:
1. bromocriptine (Parlodel)
2. pergolide (Permax)
3. both
4. neither
Vasoconstriction due to ergot alkaloids is mediated through which receptor system(s)?
1. beta adrenergic
2. alpha adrenergic
3. serotonergic
4. A & B
5. B & C
Vascular bed likely most sensitive to the actions of sumatriptan or ergotamine.
1. pulmonary
2. gastrointestinal
3. cerebral
4. renal
5. coronary
Vasospasm following ergot alkali overdosage most likely reversible by:
1. phentolamine (Regitine)
2. phenoxybenzamine (Dibenzyline)
3. nitroglycerin
4. propranolol (Inderal)
5. lisinopril (Prinvivil, Zestril)
Ergot alkaloid with highest uterine selectivity:
1. methysergide (Sansert)
2. bromocriptine (Parlodel)
3. ergotamine
4. ergonovine
5. sumatriptan (Imitrex)
Prophylactic use only in management of migraine:
1. sumatriptan (Imitrex)
2. methysergide (Sansert)
3. ergotamine
4. dihydroergotamine
5. none of the above