Medical Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice Questions

Peptic ulcer disease: select the correct mechanism and associated drug relationship:
1. Acid neutralization: calcium carbonate
2. Cytoprotection: bismuth
3. Antibacterial: bismuth
4. A, B, & C
Parietal cells (secretory elements of the gastric mucosa) release acid and intrinsic factors when activated by:
1. norepinephrine
2. atropine
3. histamine
4. none of the above
Used in management of acid-peptic ulcer disease: Least likely to produce side effects.
1. atropine
2. scopolamine
3. pirenzepine
4. all produce about equal side effects.
Mechanism by which cimetidine decrease gastric acid secretion:
1. interferes with the gastric acid pump
2. blocks cAMP action by preventing protein phosphorylation
3. competes with histamine for H-2 receptor sites
4. competes with gastrin for H-2 receptor sites
Antiulcer medication that has an antiadrogenic effect--may cause gynecomastia (breast enlargement) in some patients:
1. ranitidine (Zantac)
2. the cimetidine (Tagamet)
3. atropine
4. omeprazole (Prilosec)
H-2 receptor antagonist:
1. famotidine (Pepcid)
2. ranitidine (Zantac)
3. nizatidine (Axid)
4. all of the above.
Anti-gastric ulcer drug that binds to mucosal protein substrate and then forms a gel that coats the ulcer.
1. bismuth compounds
2. misoprostol (Cytotec)
3. sucralfate (Carafate)
4. viscous lidocaine
Anti-ulcer agent that blocks proton gnerations by parietal cells:
1. sucralfate
2. omeprazole (Prilosec)
3. ranitidine (Zantac)
4. bismuth compounds
May produce hyperplasia of enterochromaffin-like cells:
1. ranitidine (Zantac)
2. omeprazole (Prilosec)
3. cimetidine (Tagamet)
4. sucralfate
NOT classified as an H-2 receptor blocker:
1. famotidine (Pepcid)
2. terfenadine (Seldane)
3. nizatidine (Axid)
4. cimetidine (Tagamet)
H-1 blockers:
1. chlorpheniramine (Chlor-Trimeton)
2. terfenadine (Seldane)
3. famotidine (Pepcid)
4. A & B
Most effective in treating Zollinger-Ellison syndrome (caused by gastrin secreting tumors)
1. sucralfate (Carafate)
2. omeprazole (Prilosec)
3. famotidine (Pepcid)
4. misoprostol (Cytotec)
Centrally-acting anti-emetic:
1. viscous lidocaine
2. chlorpromazine (Thorazine)
3. bismuth subsalicylate
4. cholestyramine (Questran, Questran Light)
Especially effective anti-emetic for patients receiving cisplatin, an antineoplastic drug.
1. metoclopramide (Reglan)
2. ondansetron (Zofran)
3. both
4. neither
Reflux esophagitis responds best to:
1. famotidine (Pepcid)
2. cimetidine (Tagamet)
3. omeprazole (Prilosec)
4. sucralfate (Carafate)