Question # 1 (Multiple Choice) Structural analog/antimetabolite: cytotoxic immunosuppressive drug:

A) vincristine
B) cyclophosphamide
C) azathioprine
D) none of the above

Question # 2 (Multiple Choice) Immunomodulatory sedative drugs used in the management of some forms of leprosy; also effective in managing skin manifestations of lupus erythematosus

A) tacrolimus
B) cyclophosphamide
C) thalidomide
D) buproprion
E) diazepam

Question # 3 (Multiple Choice) Drug of choice in treating autoimmune hemolytic anemia:

A) cyclophosphamide plus factor XIII
B) Rho(D) immune globulin
C) prednisone
D) OKT3 monoclonal antibody
E) cyclosporine

Question # 4 (Multiple Choice) Interferes with cell cycle of activated lymphoid cells;example of the first class of hormonal agents recognized have lympholytic properties:

A) cyclosporine
B) tacrolimus
C) IFN-alpha
D) dexamethasone
E) 15-desoxyspergualin

Question # 5 (Multiple Choice) Useful in management of idiopathic thrombocytopenic purpura refractory to prednisone

A) dactinomycin
B) vincristine
C) cyclophosphamide
D) azathioprine
E) all of the above

Question # 6 (Multiple Choice) Drug of choice in treating hemolytic anemia of the newborn:

A) cyclosporine
B) prednisone
C) OKT3 monoclonal antibody
D) tacrolimus
E) Rho(D) immune globulin

Question # 7 (Multiple Choice) Clinical uses of interferon:

A) cancer treatment
B) multiple sclerosis
C) both
D) neither

Question # 8 (True/False) Type 1 hypersensitivity: cross-linking of membrane-bound IgE on blood basophils or tissue mast cells by antigen

A) true
B) false

Question # 9 (Multiple Choice) immunomodulating agents:

A) thymosin
B) interferon beta
C) interferon-gamma
D) TNF alpha
E) all the above

Question # 10 (True/False) Class 1 MHC molecules present mainly fragments of cellular antigens

A) true
B) false

Question # 11 (Multiple Choice) Inhibits antigen recognition of B-cell

A) prednisone
B) azathioprine
C) methotrexate
D) Rho(D) immune globulin
E) tacrolimus

Question # 12 (Multiple Choice) Antilymphocyte antibodies:

A) binds to the surface of T cells
B) acts mainly on small, long-lived peripheral lymphocytes
C) may be used in induction of immunosuppression
D) may be obtained by hybridoma technique for monoclonal antibody generation
E) all of the above

Question # 13 (Multiple Choice) Clinical uses of immunosuppressive drugs:

A) organ transplantation
B) hemolytic disease of the newborn
C) autoimmune disorders
D) A & C
E) A, B & C