Inflammation and Drug Management of Inflammatory Disorders

Symptoms of salicylism:
1. tinnitus
2. decreased hearing
3. vertigo
4. A & C
5. A, B & C
Phases of inflammation:
1. chronic inflammation
2. immune response
3. acute inflammation
4. A & C
5. A,B & C
Cyclooxygenase isozyme responsible for prostaglandin synthesis by cells involvet in inflammation:
1. COX-I
2. COX-II
Released at sites of tissue injury:
1. kinins
2. complement components
3. cytokines
4. neuropeptides
5. all of the above
Among these mediators: most significant increase in vascular permeability--
1. prostaglandins
2. bradykinin
3. serotonin
4. leukotrienes
5. all of the above produce similar increases in vascular permeability
Mediator in acute inflammation: pain
1. histamine
2. serotonin
3. leukotrienes
4. bradykinin
5. none of the above
Mediator of chronic inflammation (for example rheumatoid arthritis)
1. histamine
2. interleukin 1
3. bradykinin
4. neuropeptides
5. serotonin
Most nonsteroidal antiinflammatory drugs:
1. inhibit prostaglandin biosynthesis
2. weak organic bases
3. probably increase production of free radicals
4. mainly associated with guanylyl cyclase interactions
5. all the above
Initial drug of choice for treating most articular and musculoskeletal disorders (because of low-cost, safety, and efficacy)
1. glucocorticoids
2. aspirin
3. diclofenac
4. indomethacin
5. phenylbutazone
Concerning salicylates:
1. sodium salicylate an aspirin: equally effective as anti-inflammatory agents
2. aspirin: maybe more effective for analgesia
3. aspirin: hydrolyzed to acetic acid plus salicylate by tissue and blood esterases
4. urine alkalinization: increases free salicylate excretion
5. all the above