Medical Pharmacology: Pharmacology of Antidepressant Medications

**SERT to NET transporter inhibition ratios for some SSRI drugs, illustrating SERT inhibition selectivity range**

adapted from Table 15-2, reference 107 "Values shown are experimentally determined constants, K_i values, nM) for inhibiting the function of human NET, SERT and DAT expressed in cell lines."¹⁰⁷ Data was adapted from several sources.^204,205,206 The ratios are rations of inhibition constants (K_is ) which are the drug concentrations required to inhibit transport by 50%. The ratios are unitless, but the inhibition constants themselves are expressed in concentration units, in this case, nanomolar (nM, 10^-9 Molar).

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