Practice Exam I: Adrenergic Pharmacology

Anesthesia Pharmacology Chapter 6: Autonomic (ANS) Pharmacology Practice Questions

Very potent beta adrenergic receptor agonists with minimal effects on alpha adrenergic receptors:
1. propranolol (Inderal) propranolol (Inderal)
2. isoproterenol (Isuprel)
3. epinephrine
4. yohimbine (Yocon)
5. phentolamine (Regitine)
Most likely to produce a reflex-mediated bradycardia:
1. low-dose epinephrine
2. isoproterenol (Isuprel)
3. mecamylamine (Inversine)
4. methoxamine (Vasoxyl)
5. atropine
Sympathomimetic due to inhibition of transmitter uptake at noradrenergic synapses:
1. cocaine
2. ephedrine
3. dobutamine (Dobutrex)
4. epinephrine
5. yohimbine (Yocon)
Beta-2 selective agonist-- typically administered by aerosol for asthma management:
1. epinephrine
2. isoproterenol (Isuprel)
3. cromolyn sodium (Intal)
4. beclomethasone (Banceril)
5. albuterol (Ventolin,Proventil)
Useful in management of hypotensive states:low-dose increases renal blood flow:
1. dobutamine (Dobutrex)
2. isoproterenol (Isuprel)
3. dopamine (Intropin)
4. phenylephrine (Neo-Synephrine)
5. norepinephrine (Levophed)
Used to suppress premature labor:
1. isoproterenol (Isuprel)
2. losartin (Cozaar)
3. ritodrine (Yutopar)
4. phenylephrine (Neo-Synephrine)
5. clonidine (Catapres)
Produces epinephrine reversal, converting a pressor response to a deep pressor response:
1. losartin (Cozaar)
2. propranolol (Inderal)
3. metoprolol (Lopressor)
4. phentolamine (Regitine)
5. clonidine (Catapres)
Choose the incorrect statement concerning metabolic effects of sympathomimetic agents
1. Activation of beta receptors in fat cells increase lipolysis.
2. Alpha -- 2 adrenergic receptors inhibit lipolysis
3. Hepatic catecholamine effects our mediated mainly by beta adrenergic receptor activation
4. At high concentrations, catecholamines may induce a metabolic acidosis
5. Sympathomimetic drugs increase extracellular potassium
Effects of sympathomimetic agents on the gastrointestinal tract:
1. alpha -adrenergic receptor activation relaxes gastrointestinal smooth muscle
2. beta-adrenergic receptor activation relaxes gastrointestinal smooth muscle
3. alpha-2 agonists act indirectly by reducing acetylcholine release (presynaptic effect)
4. A & B
5. A,B & C
Catecholamine effects: choose the incorrect match(es):
1. Gs -- stimulatory G. protein of adenylyl cyclase
2. Gi -- inhibitory G protein of adenylyl cyclase
3. Gq -- protein coupling between beta-receptors and phospholipase C
4. A & B
5. A, B & C
Catecholamine desensitization
1. receptor sequestration
2. receptor down regulation
3. receptor phosphorylation
4. A & B only
5. A, B & C
Correct receptor type: tissues -- actions
1. alpha 1: heart: positive inotropic
2. alpha 1: pupillary dilator muscle: miosis (pupillary contraction)
3. alpha 2:cholinergic nerve terminals: facilitate transmitter release
4. beta 1: heart: decrease forests of contraction
5. beta 2:human liver: inhibits glycogenolysis
Correct receptor type: tissues: actions
1. alpha 1:most innervated vascular smooth muscle: contraction
2. alpha 2:platelets: aggregation
3. beta 2:uterine smooth muscle: smooth muscle relaxation
4. A & C
5. A, B & C
Effectively blocks reflex bradycardia following phenylephrine administration:
1. prazosin (Minipress)
2. propranolol (Inderal)
3. mecamylamine (Inversine)
4. A & C
5. A, B & C
Rate-determining enzyme reaction in catecholamine biosynthesis
1. phenylethanolamine N-methyltransferase
2. dopa decarboxylase
3. tyrosine hydroxylase
4. dopamine beta-hydroxylase
5. catechol-O-methyltransferase