Anesthesia Pharmacology
Chapter 7: Autonomic Cholinergic Pharmacology Practice Questions
Click on the correct answer.
Sympathetic Nervous System
- Ganglionic neurotransmitter: acetylcholine
- generalized response upon sympathetic activation
- thoraco-lumbar origin for preganglionic cell bodies
- A, B and C
Choline ester most susceptible to hydrolysis by acetylcholinesterase:
- carbachol
- acetylcholine
- methacholine (Provocholine)
- pilocarpine (Pilocar)
Resistant to hydrolysis by acetylcholinesterase
- carbachol (carbamylcholine)
- methacholine (Provocholine)
- both
- neither
Highest nicotinic receptor activity among choline esters:
- acetylcholine
- atropine
- methacholine (Provocholine)
- carbachol
Associated with parasympathetic activation (direct effects):
- increase heart rate
- decreased GI motility
- decrease cardiac contractility
- urinary retention
Bronchoconstriction in an asthmatic:
- metoprolol (Lopressor)
- atropine
- albuterol (Ventolin,Proventil)
- ipratropium (Atrovent)
Miosis
- pilocarpine (Pilocar)
- atropine
- both
- neither
Antimuscarinic drug with highest CNS activity
- atropine
- scopolamine
- homatropine
- muscarine
Muscarinic agent: enhances transmission through the A-V node:
- isoproterenol (Isuprel)
- atropine
- propranolol (Inderal)
- methacholine (Provocholine)
Least likely to be used as a mydriatic because of long-duration of action:
- homatropine (Isopto Homatropine)
- atropine
- cyclopentolate (Cyclogyl)
- benztropine (Cogentin)
Clinically-used to treat sinus bradycardia secondary to acute myocardial infarction:
- homatropine (Isopto Homatropine)
- atropine
- benztropine (Cogentin)
- tropicamide (Mydriacyl)
Reflex bradycardia secondary to an abrupt increase in blood pressure may be blocked by:
- atropine
- mecamylamine (Inversine)
- both
- neither
Symptoms following DFP exposure (diisopropylfluorophosphate, an organophosphate poison):
- constipation
- salivation
- decreased gastric acid secretion
- none of the above