Anesthesia Pharmacology: ANS
Introduction Practice Questions
Choose the correct answer for each question.
Sympathetic nervous system anatomy and properties:
- gangionic neurotransmitter: acetylcholine
- generalized response upond sympathetic stimulation
- thoraco-lumbar origin for preganglionic cell bodies
- all of the above
Comparing autonomic and somatic nerves:
- somatic nerves, like autonomic nerves contain ganglia.
- Most of the fibers in the vagus nerve ar sensory
- denervated smooth muscle show spontaneous activity
- motor nerves are typically unmyelinated.
Major anatomical site for integration of autonomic information:
- cerebellum
- sensory cortex
- hypothalamus
- spinal cord--dorsal horn
Division of the autonomic nervous system associated with diffuse autonomic responses.
- sympathetic
- parasympathetic
- both
- neither
Activation of the sympathetic nervous system will caus which change in the skeletal muscle versus cutaneous vascular beds.
- vasoconstriction, vasoconstriction
- vasodilatation, vasodilatation
- vasodilatation, vasoconstriction
- vasoconstriction, vasodilation
Adrenergic receptor type(s) mediating pupillary dilation
- beta-2
- alpha-1
- muscarinic
- serotonergic
Cholinergic receptor type that mediates vasodilation following low-dose i.v. acetylcholine administration:
- nicotinic
- muscarinic
- nitric oxide receptor
- substance P receptor
"True" acetylcholinesterase is found in:
- glia
- liver
- erythrocytes
- plasma
Catalyzes rate-limiting step in catecholamine biosynthesis:
- DOPA decarboxylase
- phenylethanolamine N-methyl transferase
- tyrosine hydroxylase
- dopamine-beta-hydroxylase
Inhibited by drugs such as phenelzine or tranylcypromine;
- COMT (catechol-O-methyl transferase)
- MAO (monoamine oxidase)
- choline acetyltransferase
- reuptake-I inhibitor
Concentation increased by epinephrine:
- blood free fatty acids
- blood glucose
- skeletal muscle glycogen
- A & B
Due to receptor specificity, catecholamine LEAST likely to produce bronchiolar smooth muscle relaxation:
- epinephrine
- terbutaline (Brethine)
- phenylephrine
- phentolamine (Regitine)
Alpha adrenergic receptor blocker
- phentolamine (Regitine)
- phenoxybenzamine (Dibenzyline)
- terbutaline (Brethine)
- A & B
Covalent inhibitor of acetylcholinesterse:
- edrophonium (Tensilon)
- diisopropylphosphate (DFP)
- atropine
- muscarine
Alpha-adenergic receptor agonist:
- terbutaline (Brethine)
- atropine
- methoxamine (Vasoxyl)
- isoproterenol (Isuprel)
Parasympathetic direct cardiac effects:
- decrease heart rate; increase contractility
- increase heart rate; decrease contractility
- decrease heart rate; decrease contractility
- increase AV nodal conduction velocity
Choline ester substrate for acetylcholinesterase:
- carbachol
- methacholine (Provocholine)
- both
- neither
Alkaloid agonist acting at muscarinic, cholinergic receptors:
- DFP
- pilocarpine (Pilocar)
- physostigmine (Antilirium)
- ipratropium (Atrovent)
Effective in treating both organophosphate and muscarine intoxication:
- nicotine
- echothiophate (Phospholine)
- atropine
- pilocarpine (Pilocar)
Cholinergic activity on stomach acid secretion
- increased
- decreased
- no changed
- one of the others is right