Anesthesia Pharmacology Chapter 14:
General Anesthesia Practice Questions
Inhalational anesthetic effects on circulation will be influenced by:
- presence of heart disease
- control ventilation vs. spontaneous breathing
- presence of cardioactive drugs
- A & C
- A, B & C
Inhalational agents--influence on circulatory systems:
- limited effect on myocardial contractility
- affects peripheral vascular smooth muscle tone
- changes autonomic nervous system activity
- B & C
- A, B & C
Mean arterial pressure (MAP): inhalational agents --
- dose-dependent decreases in MAP (healthy volunteers)
- reduced MAP decrease compared to that observed with surgical stimulation
- Mechanism of halothane (Fluothane)-mediated BP reduction: reduced systemic vascular resistance
- A & C
- B & C
Mechanism BP reduction: isoflurane (Forane), desflurane (Suprane), sevoflurane (Sevorane, Ultane):
- decreased heart rate
- decreased myocardial contractility
- decreased systemic vascular resistance
- decreased cardiac output
Least likely to produce a change in systemic blood pressure:
- isoflurane (Forane)
- enflurane (Ethrane)
- nitrous oxide
- halothane (Fluothane)
- sevoflurane (Sevorane, Ultane)
Reduction in mean arterial pressure following volatile anesthetic administration due to:
- direct pharmacological effects
- reduced sympathetic activation cause by preoperative anxiety
- both
- neither
Inhalational agent least likely to increase heart rate in healthy individuals
- isoflurane (Forane)
- halothane (Fluothane)
- desflurane (Suprane)
- sevoflurane (Sevorane, Ultane)
Isoflurane (Forane)-mediated increase in heart rate prevented by preoperative (just before induction) administration of:
- atropine
- fentanyl (Sublimaze)
- morphine
- B & C
- A, B & C
Isoflurane (Forane) and blood pressure:
- neonates: increase blood-pressure, increased heart rate
- elderly patients: reduced heart rate responses
- younger patients: reduced heart rate
Inhalational agent most likely to cause dose-dependent decrease in cardiac output {normal volunteer}
- desflurane (Suprane)
- isoflurane (Forane)
- halothane (Fluothane)
Inhalational agent least likely to affect systemic vascular resistance in normal volunteers
- isoflurane (Forane)
- halothane (Fluothane)
- desflurane (Suprane)
- sevoflurane (Sevorane, Ultane)
Mechanism(s) of isoflurane (Forane)-mediated reduction in systemic vascular resistance:
- increased cutaneous blood flow
- increased skeletal muscle blood flow
- both
- neither
Administration of a volatile anesthetic for longer than five hours results in the recovery from cardiac depressing effects:
- true
- false