Anesthesia Pharmacology Chapter 14:
General Anesthesia Practice Questions
Factors determining anesthetic partial pressure in arterial blood:
anesthetic concentration in the inspired air
pulmonary ventilation
transfer of gas from blood to body tissues
A & C
A, B & C
Depth of anesthesia primarily depends on:
patient age
Rate of hepatic anesthetic metabolism
anesthetic partial pressure (tension) in brain
rate of transfer of gas from the blood to alveoli
rate of redistribution of the anesthetic from the brain to other tissues
Fastest rate of rise of arterial gas tension (as% of inspired tension):
halothane (Fluothane)
ether
nitrous oxide
isoflurane (Forane)
all are equal
Differences between anesthetics in terms of rate of rise of arterial gas tension are primarily due to:
different rates of anesthetic metabolism
differential excretion rates
anesthetic physical properties, e.g. solubility
Relationship between the rate of rise of anesthetic concentration in the blood and rate of rise of anesthetic concentration in the brain.
direct
inverse
Pulmonary ventilation --factor that accelerates attainment of brain anesthetic concentration
respiratory depression
overventilation during induction
both
neither
Anesthetic solubility in the blood:
The more soluble in age and is in the blood the less must be dissolved to raise its partial pressure (tension)
Inhalational agent solubility is a relatively unimportant factor in determining the speed of induction recovery
Induction times may be prolonged with methoxyflurane because of its high solubility
Pulmonary blood flow & gas transfer from alveoli to blood
Pulmonary blood flow is inversely related to cardiac output
With higher pulmonary flow, there is an initial relative decrease in the rate of rise of anesthetic tension
both
neither
Partial pressure in arterial and mixed venous blood & gas transfer from alveoli to blood:the amount of dissolved anesthetic and mixed venous blood returning to the lung has no effect on the rate of transfer anesthetic gas into the blood
true
false
Factors that determine how quickly anesthetics pass from the inspired gas to the blood:
Anesthetic solubility in the blood
Partial pressures in arterial and mixed venous blood
Pulmonary blood flow
A & C
A, B & C
Factors affecting transport of anesthetic from arterial blood to tissues:
rate of delivery of anesthetic to tissue
solubility of the gas in tissues
difference impartial pressures between arterial blood and tissue