Physiological effect NOT typically associated with opioids:
- constipation
- constriction of biliary smooth muscle
- enhanced renal function
- limited direct cardiovascular effects
- may prolong labor
Mixed agonist-antagonist:
- naloxone (Narcan)
- naltrexone (ReVia)
- hydromorphone (Dilaudid)
- nalbuphine (Nubain)
- diphenoxylate (Lomotil)
Used in treatment diarrhea:
- difenoxin
- diphenoxylate (Lomotil)
- loperamide (Imodium)
- B & C
- A,B & C
Contraindications/caution for opioid use:
- patients with Addison's disease
- patients with impaired pulmonary function
- patients with head injury
- B & C
- A, B & C
Useful drug(s) for opioid detoxification and maintenance of chronic relapsing heroin addict:
- methadone (Dolophine)
- levomethadyl acetate
- propoxyphene (Darvon)
- A & B
- A, B & C
Effective antitussive(s)
- codeine
- morphine
- dextromethorphan
- oxycodone (Roxicodone)
- all the above
Opioid antagonist with shortest duration of action:
- naloxone (Narcan)
- nalmefene (Revex)
- naltrexone (ReVia)
- all about equal duration of action
- these agents are not opioid antagonists
Routes of opioid agonist administration:
- transdermal
- patient-controlled analgesia (PCA)
- intranasal
- A & B
- A, B & C
Signs and symptoms of acute opioid withdrawal (abstinence syndrome)
- yawning
- lacrimation
- hyperventilation
- diarrhea
- all the above
In obstetrical applications:opioid less likely to produce respiratory depression in the newborn
- meperidine (Demerol)
- morphine