An opioid with both agonist and antagonist properties:
- morphine
- meperidine (Demerol)
- pentazocine (Talwain)
- oxycodone (Roxicodone)
Neuroendocrine effects of morphine
- decrease in corticotropin releasing factor
- decrease in gonadotropin-releasing factor
- decrease in cortisol levels
- A, B & C
Physiological effects of morphine:
- chronic diahrrea
- mydriasis
- respiratory depression
- A & C
Physiological effects of meperidine:
- miosis
- cns depressive effects due to metabolite.
- nausea
- A & C
Narcotic agonists: most serious adverse effect:
- cardiac arrhythmias
- respiratory depression
- convulsions
- endogenous depression