Carbonic Anhydrase Inhibitors

Acetazolamide (Diamox)
1. increases bicarbonate reabsorption in the proximal tubule
2. increases secretion of bicarbonate by the ciliary body of the eye into aqueous humor
3. may be effective in treatment metabolic alkalosis
4. major clincial application is the kidney--to produce a bicarbonate-driven diuresis
5. main renal site of action is the thick ascending loop of Henle
Predominate renal location of carbonic acid anhydrase:
1. cytoplasm of the epithelial cells
2. basolateral membranes
3. luminal membrane of the proximal tubule
4. A & B
5. A, B & C
Acetazolamide (Diamox) secretion:
1. not secreted
2. excreted by the S2 segment of the proximal tubule
3. collecting duct
4. distal convoluted tubule
5. ascending Loop of Henle
Topically-active carbonic anhydrase inhibitor for ocular use:
1. acetazolamide (Diamox)
2. furosemide (Lasix)
3. chlorothiazide (Diuril)
4. dorzolamide (Trusopf)
5. bumetanide (Bumex)
Urate stone formation is inhibited at least temporarily by acetazolamide (Diamox) mainly because:
1. acetazolamide (Diamox) decreases urine flow
2. acetazolamide (Diamox) decreases the amount of urate excreted
3. acetazolamide (Diamox) causes an increase in urine pH
4. acetazolamide (Diamox) causes a decrease in urine pH
5. A & C
Acetazolamide (Diamox) toxicity:
1. renal stones
2. hyperchloremic metabolic alkalosis
3. potassium wasting
4. A & C
5. A, B & C
Clinical uses of acetazolamide (Diamox):
1. urinary alkalinzation
2. metabolic alkalosis
3. acute mountain sickness
4. some forms of epilepsy
5. all of the above