Anesthesia Pharmacology: Autonomic Adrenergic
Practice Questions
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Isoproterenol (Isuprel): cardiopulmonary effects:
- positive inotropism
- A & C
- increases peripheral resistance
- B & C
- positive chronotropism
ß-2 selective agonist:
- metaproterenol (Alupent)
- labetalol (Trandate, Normodyne)
- phentolamine (Regitine)
- epinephrine
- phenylephrine (Neo-Synephrine)
Prevents blood pressure reduction seen with isoproterenol (Isuprel):
- atropine
- esmolol (Brevibloc)
- propranolol (Inderal)
- phenylephrine (Neo-Synephrine)
- phentolamine (Regitine)
Immediate biosynthetic precursor of epinephrine:
- metaraminol
- doapmine
- L-DOPA
- isoproterenol
- norepinephrine
Physiological effects associated with isoproterenol (Isuprel):
- decreased heart rate
- increased GI motility
- increased peripheral resistance
- bronchoconstriction
- increased blood glucose
Increases both magnitude of the blood pressure increase due to phenylephrine and the heart rate decrease due to methacholine:
- mecamylamine (Inversine)
- timolol (Blocadren)
- atropine
- clonidine (Catapres)
- nitroprusside sodium (Nipride)
Drug causes pupillar dilation with no effect on accommodation:
- neostigmine (Prostigmin)
- phentolamine (Regitine)
- pilocarpine (Pilocar)
- atropine
- phenoxybenzamine (Dibenzyline)
The magnitude of the cardiovascular response to norepinephrine is increased by cocaine because:
- cocaine increases conversion of norepinephrine to phenylephrine
- cocaine inhibits norepinephrine reuptake
- cocaine decreases N.E. metabolism by MAO
- cocaine decreases cholinergic receptor number
- cocaine increases N.E. receptor number
Albuterol (Ventolin,Proventil):
- decreases myocardial contractility
- bronchodilation
- significant heart rate increase
- by I.V. injection only
-
α-adrenoceptor antagonist
Therapeutic use of esmolol (Brevibloc):
- bronchial asthma
- positive inotrope in CHF
- antihypertensive
- antiarrhythmic drug
- renal vasodilator