Medical Pharmacology Chapter 5: Pharmacology of Adrenergic Drugs

Epinephrine beneficial effect(s) in asthma:
1. Decreasing bronchial secretion
2. Decreasing mucosal congestion
3. Possible reduction in antigen-induced inflammatory mediator release from mast cells
4. Direct bronchodilator effects
5. A & B
6. B & C
7. A, B & C
8. A, B, C & D (all actions of epinephrine contribute to beneficial effects in asthma)
Least likely to exhibit substantial anti-inflammatory effects:
1. Leukotriene receptor blockers
2. Epinephrine
3. Glucocorticoids
Due to pharmacological and chemical properties, epinephrine is a particularly important and powerful CNS stimulant.
1. True
2. False
Epinephrine and metabolism:
1. Epinephrine administration reduces blood glucose.
2. Epinephrine administration is associated with a reduction in blood lactate.
3. Both
4. Neither
Epinephrine and insulin secretion:
1. Epinephrine through activation of α₂ receptors inhibits insulin secretion.
2. Epinephrine through β₂ receptors promotes insulin secretion.
3. Both
4. Neither
The predominant effect of epinephrine with respect insulin secretion is mediated by activation of α₂ receptors the activation of which inhibits insulin secretion.
1. True
2. False
Concerning autonomic effects on fat cells:
1. Sympathetic system activation promotes lipolysis and thermogenesis.
2. Parasympathetic systems inhibit lipolysis
3. Both
4. Neither
Reduction of secretion from pancreatic acini is mediated by α-type adrenergic receptors.
1. True
2. False
Control of pineal gland melatonin synthesis is mainly mediated by autonomic cholinergic systems.
1. True
2. False
Autonomic nervous system control of the spleen capsule:
1. Contraction by α-type adrenergic receptor activation
2. Relaxation mediated by β₂ adrenergic receptors.
3. Both
4. Neither