Medical Pharmcology: Cholinergic Pharmacology Practice Questions

Sympathetic Nervous System
1. Ganglionic neurotransmitter: acetylcholine
2. generalized response upon sympathetic activation
3. thoraco-lumbar origin for preganglionic cell bodies
4. A, B and C
Choline ester most susceptible to hydrolysis by acetylcholinesterase:
1. carbachol
2. acetylcholine
3. methacholine (Provocholine)
4. pilocarpine (Pilocar)
Resistant to hydrolysis by acetylcholinesterase
1. carbachol (carbamylcholine)
2. methacholine (Provocholine)
3. both
4. neither
Highest nicotinic receptor activity among choline esters:
1. acetylcholine
2. atropine
3. methacholine (Provocholine)
4. carbachol
Associated with parasympathetic activation (direct effects):
1. increase heart rate
2. decreased GI motility
3. decrease cardiac contractility
4. urinary retention
Bronchoconstriction in an asthmatic:
1. metoprolol (Lopressor)
2. atropine
3. albuterol (Ventolin,Proventil)
4. ipratropium (Atrovent)
Miosis
1. pilocarpine (Pilocar)
2. atropine
3. both
4. neither
Antimuscarinic drug with highest CNS activity
1. atropine
2. scopolamine
3. homatropine
4. muscarine
Muscarinic agent: enhances transmission through the A-V node:
1. isoproterenol (Isuprel)
2. atropine
3. propranolol (Inderal)
4. methacholine (Provocholine)
Least likely to be used as a mydriatic because of long-duration of action:
1. homatropine (Isopto Homatropine)
2. atropine
3. cyclopentolate (Cyclogyl)
4. benztropine (Cogentin)
Clinically-used to treat sinus bradycardia secondary to acute myocardial infarction:
1. homatropine (Isopto Homatropine)
2. atropine
3. benztropine (Cogentin)
4. tropicamide (Mydriacyl)
Reflex bradycardia secondary to an abrupt increase in blood pressure may be blocked by:
1. atropine
2. mecamylamine (Inversine)
3. both
4. neither
Symptoms following DFP exposure (diisopropylfluorophosphate, an organophosphate poison):
1. constipation
2. salivation
3. decreased gastric acid secretion
4. none of the above