Anesthesia Pharmacology: Antiarrhythmic Drugs Practice Questions

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  1. Which one(s) of the following statements best describe(s) the mechanism of action of adenosineas an antiarrhythmic agent?
    1.   Adenosine acts through specific G protein-coupled ß-adrenergic receptors
    2.   Adenosine activates acetylcholine sensitive potassium currents in the atrium as well as in the SA and AV nodes.
    3.   Adenosine enhances electrophysiological effects of intracellular cyclic AMP secondary to sympathetic stimulation.
    4.   Adenosine increases calcium currents and exerts antiarrhythmic activity by decreasing AV nodal refractoriness and by inhibiting delayed afterdepolarizations caused by sympathetic activity.
    5.   A&C
    6.   D only

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