Anesthesia Pharmacology Practice Questions

Choose the correct response response(s) concerning the pharmacology of procainamide.
1. Procainamide is an analog of procaine, a local anesthetic.
2. Procainamideone exhibits electrophysiological effects similar to quinidine and shares quinidine's anti-vagal and alpha-adrenergic receptor antagonism.
3. Following IV infusion, procainamide appears better tolerated when compared with quinidine.him
4. Long-term oral administration of procainamide is well tolerated and effective.
5. A & C
6. A, B & C
7. D only
Which one(s) of the following statements concerning procainamide is/are correct?
1. Procainamide belongs to the class I, subgroup 1A, group of antiarrhythmic drugs.
2. Procainamide is a sodium channel blocker but also exhibits a non-specific antagonism of potassium channels which mediates prolongation of the cardiac action potential duration.
3. Procainamide directly depresses both the SA and AV nodes.
4. A & B
5. A, B & C
Non-cardiac-related procainamide effects include(s):
1. Ganglionic blockade
2. Increased peripheral resistance
3. Hypotension (associated with IV administration)
4. A & C
5. A, B & C
Procainamide'smajor metabolite, N-acetyl procainamide, exhibits both the parent drugs sodium-channel antagonism as well as cardiac action potential prolongation.
1. True
2. False
Major adverse effects of high concentration (>10 ug/ml) procainamide administration, especially noted during IV route of administration include(s):
1. Hypotension
2. Significant reduction in action potential conduction velocity
3. Both
4. Neither
With long-term procainamide administration, most patients will exhibit biochemical indication of drug-induced lupus syndrome,, including circulating antinuclear antibodies.
1. True
2. False
Procainamide and/or N-acetylprocainamide can accumulate in patients with renal failure to the point that toxic drug plasma levels may be reached.
1. True
2. False
Substantial accumulation of an N-Acetyl procainamide may predispose patients to torsades de pointes.
1. True
2. False
Procainamide elimination involves both hepatic metabolism (to N-acetylprocainamide) and renal excretion.
1. True
2. False
Choose the correct statement(s) concerning procainamide its therapeutic use.
1. Procainamide is effective against most atrial arrhythmias.
2. Procainamide is effective against most ventricular arrhythmias.
3. Both
4. Neither