Anesthesia Pharmacology Practice Questions: Antiarrhythmic Drugs

Amiodaron although categorized as a class 3 agent exhibits electrophysiological characteristics of all four categories of antiarrhythmic drug classes (Vaughan-Williams classification).
1. True
2. False
Choose the correct statemen(s) concerning electrophysiological effects of amiodarone.
1. IV amiodarone exhibits inhibitory actions on both sodium and calcium currents.
2. Oral amiodarone, after a few days of administration, namely effects of recurrence.
3. Chronic amiodarone administration blocks a number of different potassium currents (e.g. IKr, IKs, Ik1)
4. All of the above
Anticholinergic effects caused by aminodarone administration occurs as a result of:
1. Noncompetitive binding to ß-adrenergic receptors.
2. Inhibition of adrenergic agonist-induced increases in the adenylate cyclase enzyme activity.
3. A
4. B
5. A & B
Amiodarone has clinical application in managing many types of both supraventricular and ventricular arrhythmias.
1. True
2. False
IV amiodarone is now considered the first-line drugs for posttreatment in prophylaxis of ventricular fibrillation
1. True
2. False
Which one(s) of the following clinical presentations may respond well to amiodarone administration?
1. Slowing fast ventricular following rates in atrial fibrillation (due to A-V blockade in critically ill individuals).
2. Treatment and prevention of ventricular fibrillation in ventricular arrhythmias resistant to other interventions (especially in the hemodynamically unstable patient).
3. Both
4. Neither
The most significant adverse effect associated with amiodarone is renal failure.
1. True
2. False