AnesthesiaPharmacology Practice Questions: Antihypertensive Drugs

Aliskiren (Tectuma) is classified as which one of the following drug groups?
1. Angiotensin converting enzyme inhibitor (ACE inhibitor)
2. Calcium channel blocker
3. Renin inhibitor
4. Angiotensin receptor blocker
5. None of the above
Which one of the following drug or drug combinations provide the most efficient renin-angiotensin system inhibition?
1. Captopril
2. Lisinopril
3. Eprosartan
4. Trandolapril + verapamil
5. Aliskiren
Which one(s) of the following effects are associated with aliskiren administration given for hypertension management?
1. A limitation of left ventricular hypertrophy
2. A reduction in albuminuria
3. Effective blood pressure reduction
4. All of the above
For treating hypertension in patients with type 2 diabetes, the combination of aliskiren with ACE inhibitors or angiotensin receptor antagonists is more beneficial than aliskiren monotherapy.
1. True
2. False
Mechanism of antihypertensive action of aliskiren:
1. Prevention of renin synthesis
2. Increased rate of renin metabolic degradation
3. Prevention of angiotensinogen cleavage by renin
4. Angiotensin-converting enzyme inhibition
5. Prevention of calcium release in vascular smooth muscle
Biological activity/activities associated with angiotensin-converting enzyme inhibitors (ACE inhibitors) include(s):
1. Inhibition of the renin-angiotensin-aldosterone system
2. Inhibition of bradykinin degradation
3. Increase synthesis of vasodilating prostaglandins
4. Decrease in autonomic, sympathetic activity
5. A&C
6. A, B & C
7. A,B,C & D
Use of angiotensin-converting enzyme inhibitors as monotherapy for hypertension is effective in about this percentage of hypertensive patients.
1. 10%
2. 25%
3. 40-50%
4. Greater than 70%
Drugs in this pharmacological class are considered agents of choice in hypertensive patients who also are type 1 diabetics with evidence of kidney dysfunction.
1. Calcium channel blockers
2. Angiotensin receptor blockers
3. Angiotensin-converting enzyme (ACE) inhibitors
4. ß-adrenergic receptor antagonists
5. Adrenergic receptor antagonists exhibiting both alpha and ß receptor blockade
Choose the correct statement(s) concerning the use of the ACE inhibitor ramipril:
1. Reduction in nonfatal myocardial infarctions
2. Reduction in new-onset congestive heart failure
3. Reduction in new-onset diabetes individuals with high risk for vascular incidents.
4. Reduction in the number of cardiovascular deaths
5. A & C
6. D only
7. A, B, C & D
Administration of an ACE inhibitor typically with a diuretic and ß-adrenergic receptor antagonist is considered a drug of choice in:
1. Patients with heart failure
2. Patients (asymptomatic) with decreased ejection fraction
3. Both
4. Neither