Anesthesia Pharmacology Practice Questions: Opioid Analgesics

Methadone is classified as a long-acting mu opioid receptor agonist with activities comparable to those seen with morphine.
1. True
2. False
Analgesic effects associated with methadone is mainly a consequence of:
1. The L-Methadone isomer
2. The D-methadone isomer
3. Both
Pharmacological properties/property associated with methadone include/includes:
1. Pharmacological effects following oral administration
2. Suppression of withdrawal symptoms and physically dependent patients over an extended period of time.
3. Effective even with repeated dosing
4. A & B
5. B & C
6. A. B & C
Methadone differs from morphine in that methadone does not suppress bowel motility or cough.
1. True
2. False
Concerning methadone absorption and metabolism: which of the following statements are statements is/are correct?
1. Methadone is well absorbed from the G.I. tract.
2. Methadone exhibit substantial binding to plasma proteins.
3. Methadone is metabolized extensively by the liver.
4. A & B
5. A & C
6. A, B & C
By contrast other opioids, methadone and ministration appears associated with prolonged cardiac QT syndrome and this effect is additive in patients taking other drugs known to lengthen the QT interval.
1. True
2. False
Major clinical uses of methadone:
1. Management of opioid abstinence effects
2. Treatment of heroin users
3. Both
4. Neither
In the use of oral methadone over the long-term, patients do not exhibit withdrawal effects following naloxone administration.
1. True
2. False
D-propoxyphene (Darvon et al.) administration has been associated with a number of toxicities and, as a result, is being replaced in the clinical setting by safer agents.
1. True
2. False
In the US, propoxyphene is not recommended in individuals exhibiting suicidal behavior or with a history of suicidal ideation.
1. True
2. False