Anesthesia Pharmacology Practice Questions: Sedative-Hypnotic Drugs

Choose the correct statement(s) about Flurzepam (Dalmane):
1. Flurzepam, the parent compound, has a half-life of about two hours.
2. A major active metabolite N-des-alkyl-flurzepam has a half-life of about 50-100 hours
3. Both
4. Neither
Benzodiazepines are often metabolized by the liver cytochrome P450 microsomal metabolizing system, CYP3A4 and CYP2C19 are predominantmetabolizing isoforms.
1. True
2. False
Which one(s) of the following because they inhibit CYP3A4,a hepatic cytochrome P450 metabolizing isoform, may influence benzodiazepine metabolism?
1. Erythromycin
2. Ketoconazole
3. Grapefruit juice
4. A & C
5. B & C
6. A, B & C
Concerning benzodiazepine therapeutic uses, many benzodiazepines can be used interchangeably.
1. True
2. False
Which one of the following benzodiazepines would be most likely used to manage insomnia?
1. Clorazepate
2. Alprazolam
3. Estazolam
4. Lorazepam
Which one of the following benzodiazepines would be most likely used in the preanesthetic and intraoperative setting?
1. Lorazepam (Ativan)
2. Chlordiazepoxide (Librium)
3. Midazolam (Versed)
4. Quazepam (Doral)
Which one of the following benzodiazepines the most likely used to manage anxiety disorders?
1. Oxazepam (Serax)
2. Triazolam (Halcion)
3. Temazepam (Restoril)
4. Midazolam (Versed)
Following benzodiazepine administration, at the time of the highest plasma concentration, which one(s) of the following untoward effects might be associated with hypnotic doses?
1. Confusion
2. Anterograde amnesia
3. Lassitude
4. Lightheadedness
5. All of the above
Intensity and likelihood of CNS toxicity due to benzodiazepines often increase with patient age.
1. True
2. False
Prolonged, long-term benzodiazepine use may result in both drug dependence and abuse.
1. True
2. False
Flunitrazepam (Rohypnol) has been described as a "date-rape drug."
1. True
2. False