Anesthesia Pharmacology: Sedative-Hypnotic Drug Practice
Questions
Click on the correct answer.
Barbiturates have for most purposes been superseded by benzodiazepines, a safer drug class.
- True
- False
Which one of the following is more sensitive to the effect of barbiturates?
- Peripheral nervous system
- Central nervous system
Enhancement of neuronal inhibition by barbiturates occur at synapses using this neurotransmitter.
- Acetylcholine
- Norepinephrine
- Lysine
- Adenosine
- GABA
Which one(s) of the following statements concerning barbiturates is/are correct?
- Barbiturates promote binding of GABA to GABA receptors in a manner dependent on chloride ion, an effect shared by benzodiazepines.
- Barbiturates enhanced benzodiazepine binding at the GABA receptor.
- Both
- Neither
Which one(s) of the following statements concerning barbiturates correct?
- Barbiturates activate inhibitory GABA receptors.
- Barbiturates inhibit excitatory AMPA receptors
- Both
- Neither
The range of CNS depression caused by barbiturate administration can extend from mild sedation to general anesthesia.
- True
- False
Concerning the development of tolerance to barbiturates:
- Pharmacodynamic or functional tolerance to barbiturates may occur
- Pharmacokinetic-based tolerance to barbiturates may occur
- Both
- Neither
Concerning pharmacokinetic and pharmacodynamic tolerance to barbiturates, choose which one(s) of the following statements is/are correct?
- With chronic administration of slowly increasing doses, pharmacodynamic tolerance progressively develops over a period of weeks to months.
- Typically pharmacokinetic tolerance peaks after a few days to a week.
- Both
Neurogenic-based respiratory drive may be completely suppressed at a barbiturate dose three times higher than the normal hypnotic dose.
- True
- False
Prominent effects of barbiturate on the liver are associated with the cytochrome P450 microsomal drug-metabolizing system.
- True
- False