Anesthesia Pharmacology Chapter 29: Diabetes Management Practice Questions

Type 2 diabetes characterization:
1. Dysregulation of glucose homeostasis
2. Impairment of both insulin secretion and action
3. Both
4. Neither
Being overweight or obese is frequently associated with type 2 diabetes occurring in about:
1. 25% of affected individuals
2. 40% of affected individuals
3. 60% of affected individuals
4. 80% of affected individuals
5. Greater than 95% of affected individuals
Effectiveness of insulin action in the maintenance of appropriate plasma glucose levels depends upon which one(s) of the following:
1. Plasma insulin levels as determined by islet beta cell activity.
2. Insulin sensitivity an important target tissue such as liver, fat, and skeletal muscle.
3. Both
4. Neither
Type 2 diabetes exhibits a significant,strong genetic contribution.
1. True
2. False
Should an individual have a diabetic parent or sibling, there is a relative 4-fold increase disease risk.
1. True
2. False
Concerning reduced islet beta cell sensitivity to glucose in type 2 diabetes:
1. Responsiveness to other "insulinotropic" gastrointestinal hormones is retained.
2. Responsiveness to neural signaling is retained.
3. Both
4. Neither
Reduced sensitivity of the beta-cell to glucose and losses of responsiveness to other stimuli results in:
1. A slowing of the natural increase in blood glucose following meals.
2. A rapid increase in hepatic glucose release during fasting.
3. Both
4. Neither
In most individuals with type 2 diabetes increasing treatment is required to maintain glucose control as a result of a progressive decrease in Beta-cell mass and function.
1. True
2. False
In type 2 diabetes dysregulation of glucagon secretion is observed, with excessive glucagon secretion common.
1. True
2. False
Insulin sensitivity is reflected in the amount of glucose removed from blood following a fixed insulin dose.
1. True
2. False