Anesthesia
Pharmacology: Gastrointestinal Pharmacology Practice Questions
Choose the correct answer for each question.
Prokinetic drugs:
- Increase coordinated gastrointestinal motility.
- Promote transit of material through the G.I. tract.
- Both
- Neither
An example of an effective prokinetic agent would be represented by muscarinic receptor agonist or by inhibitors of the enzyme acetylcholinesterase.
- True
- False
Potential clinical use(s) of agents selectively stimulating G.I. motor activity (prokinetic drugs):
- Helpful in managing gastroesophageal reflux disease (GERD)
- Helpful in enhancing gastric emptying and postoperative ileus or chronic intestinal "pseudo-obstruction."
- Both
- Neither
Primary neurotransmitter receptor system constituting the focus for agents with therapeutic potential for improving gastrointestinal applications.
- Cholinergic
- Dopaminergic
- Kinins
- Serotonergic (5-HT)
Focus of 5-HT drug development for G.I. applications:
- 5-HT3 receptor blockers
- 5-HT4 receptor agonists
- Both
- Neither
Bethanechol, cholinergic agonist, has been previously used for management of GERD and gastroparesis.
- True
- False
Intravenous neostigmine:
- May be used in hospitalized patients with acute bowel distention i.e. Ogilvie's syndrome.
- Enhances small intestine and colonic emptying
- Both
- Neither
Cholinergic effects associated with neostigmine as well as cholinergic agonist generally:
- Vomiting
- Bradycardia
- Diarrhea
- A & B
- B & C
- A & C
- A, B & C