Anesthesia Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice Questions

Adverse effect(s) associated with octreotide administration:
1. Steatorrhea secondary to impaired pancreatic secretion
2. Long-term administration of octreotide may cause gallstones (or sludge) in over half of patients.
3. Both
4. Neither
Octreotide administration can lead to:
1. Hyperglycemia
2. Hypoglycemia
3. Both
4. Neither
Extended treatment with octreotide can result in:
1. Hypothyroidism
2. Tachycardia
3. Both
4. Neither
Octreotide of somatostatin (SST) are effective in treating acute pancreatitis.
1. True
2. False
Telotristat ethyl (Xermelo):
1. Reduces diarrhea due to carcinoid tumors.
2. Mechanism of action involves inhibiting tryptophan hydroxylase which is the rate-limiting enzyme associated with serotonin biosynthesis.
3. Both
4. Neither
Serotonin secretion (5-HT secretion) induces fluid secretion and enhances motility in the G.I. tract.
1. True
2. False
Telotristat ethyl:
1. Absorbed following oral administration, then converted to the active agent, Telotristat.
2. Telotristat Is administered along with somatostatin analogs in treating diarrhea in carcinoid syndrome.
3. Both
4. Neither