Drug(s) appropriate for treating mild inflammatory bowel disease (IBD).
5-aminosalicylates (Crohn's
colitis or ulcerative colitis)
Budesonide (Crohn's ileitis)
Both
Neither
Drug(s) Are appropriate for treating patients with "moderate" inflammatory bowel disease or for those patients failing treatment options for "mild" disease.
Oral corticosteroids
Immunomodulators
Anti-TNF antibodies
A & B
B & C
A & C
A, B & C
Example(s) of immunomodulator agent(s) useful in managing inflammatory bowel disease patients exhibiting moderate disease.
Methotrexate
Mercaptopurine
Both
Neither
Azathioprine is an example of an immunomodulator that may be helpful in promoting or maintaining inflammatory bowel disease remission.
True
False
Inflammatory bowel disease patients who have not responded to either tumor necrosis factor (TNF) blockers or immunomodulators and who exhibit severe Crohn's presentations may be given natalizumab (Tysabri).
True
Cyclosporine is mainly given to patients with ulcerative colitis who have not responded to intravenous corticosteroid treatments.
True
False
In the gastrointestinal setting, this/these agents represent commonly used oral glucocorticoid(s)
Prednisone
Prednisolone
Both
Either
In treating moderate-to-severe inflammatory bowel disease patients, some patients appear glucocorticoid-unresponsive or "steroid-resistant." These, even with high-dose steroids given for extended periods, are unlikely to improve.
True
False
Concerning use of glucocorticoids in inflammatory bowel disease patients.
Some patients, considered "responsive" improve as judged clinically within a week or two, remaining in remission allowing for steroid slow discontinuation.
Some patients exhibit steroid dependency and relapse if th steroid dose is slowly discontinued.