Question # 1 (Multiple Choice) Type of "chemical force" or bond that may drive the interaction between lipophilic drugs and biological membrane lipids:

A) covalent
B) electrostatic
C) hydrophobic

Question # 2 (Multiple Choice) Example(s) of a covalent drug-receptor interaction:

A) receptor-activated phenoxybenzamine
B) DNA-anticancer alkylating agent
C) both
D) neither

Question # 3 (Multiple Answer) Saturable transport systems:

A) passive diffusion
B) aqueous diffusion
C) lipid diffusion
D) active transport -- carrier mediated
E) facilitated diffusion -- carrier mediated

Question # 4 (Multiple Choice) A neutral molecule that can reversibly dissociates into an anion (negatively charged molecule) and a proton (a hydrogen ion):

A) weak acid
B) weak base

Question # 5 (Multiple Answer) Factors that influence the passive movement of drugs down a concentration gradient:

A) drug concentration differences on either side of the barrier (e.g. membrane)
B) thickness of the diffusion pathway
C) mobility of the drug molecule in the medium of the diffusion path (permeability)

Question # 6 (Multiple Choice) A weak base drug has a pKa of 6.5. If the pH of the medium is 7.5, the drug is

A) mainly neutral
B) mainly positively charged

Question # 7 (Multiple Answer) Concerning renal drug excretion:

A) almost all drugs are filtered by the glomerulus
B) a lipid-soluble, filtered drug will likely be reabsorbed by passive diffusion
C) pH partitioning (the drug is ionized at the urinary pH) enhances excretion
D) weak acids are excreted faster in alkaline urinary pH

Question # 8 (Multiple Choice) Of these "chemical forces" or bonds, the strongest:

A) van der Waals
B) dipole
C) covalent
D) hydrophobic

Question # 9 (Multiple Choice) A neutral molecule that can form a cation (a positively charged molecule) by combining with a proton (a hydrogen ion):

A) weak acid drug
B) weak base drug

Question # 10 (Multiple Choice) Most drugs have molecular weight between:

A) 1-10
B) 10-100
C) 100-500
D) > 500

Question # 11 (Multiple Choice) The pKa of a weak acid drug is 6.5. If the pH of the medium is 5.5, the drug will be:

A) mainly neutral
B) mainly ionized and negatively charged

Question # 12 (Multiple Choice) The process in which a substance is engulfed by the cell membrane and carried into the cell body pinching of of the newly formed vesicle inside the membrane.

A) lipid diffusion
B) carrier-mediated transport
C) exocytosis
D) endocytosis
E) aqueous diffusion

Question # 13 (Multiple Choice) A type of diffusion that usually occur is within larger body compartments (interstitial space, cytosol) and across epithelial membrane tight junctions and through pores in blood vessel endothelial lining.

A) lipid effusion
B) aqueous diffusion
C) carrier-mediated
D) endocytosis
E) exocytosis