Medical Pharmacology Chapter 3: Pharmacodynamic Practice Questions

Pharmacodynamics describes both drug effects and mechanisms of action.
1. True
2. False
Drug receptors by contrast to drug "acceptors" do not change physiological and biochemical responses but are more likely to change pharmacokinetics describing a drug's actions.
1. True
2. False
Example/examples of more recently introduced drugs have been described as "therapeutic biologics" and include/includes:
1. Monoclonal antibodies
2. Engineered enzymes i.e. by genetic manipulation for example
3. Both
4. Neither
Examples of a new generation of pharmacological agents allow directed genome editing, taking advantage of RNAi, antisense oligonucleotides, and CHRISPR/Cas9 technology
1. True
2. False
Characteristic/characteristics of many drug receptors:
1. These drug receptors are usually proteins and interact with endogenous, small molecules which serve regulatory functions
2. These drug receptors are described as "physiological receptors."
3. Both
4. Neither
Drugs which bind to the same specific receptor site as the endogenous (normally found in the body) ligand and exert the same regulatory effects typically describes/describe:
1. Agonist
2. Antagonist
3. Both
4. Neither
Mechanism/mechanisms of drug antagonists:
1. Chemical antagonism
2. Functional antagonism
3. Both
4. Neither
Usually drug antagonism involves an antagonist interacting in a competitive way with the agonist for either the same or at an overlapping receptor site. This type of antagonism is described as a "syntopic interaction."
1. True
2. False
Partial agonists, as the name suggests, our agonists that activate the receptor to a degree less than the full agonist.
1. True
2. False
Concerning "inverse agonists":
1. These agents stabilize receptors in an inactive conformation
2. Inverse agonists, as well as partial agonists, appear as competitive antagonists in the presence of a full agonist.
3. Both
4. Neither