Anesthesia Pharmacology:
Pharmacokinetic Practice Questions
Choose the correct answer for each question.
Primary site for drug metabolism:
- stomach
- small intestine
- kidney
- muscle
- liver
Drug mixed-function oxidase (p450) mainly localized:
- mitochondrial fraction
- cell membranes
- golgi bodies
- microsomal fraction
- nucleolus
Most drugs are oxidized in the:
- smooth endoplasmic reticulum
- rough endoplasmic reticulum
- smooth and rough about equally
- nucleus
- none of the above
Drug biotransformation:
- mainly, but not exclusively in the liver
- products are usually less biologically active
- biotransformation products can be toxic
- A & B
- A, B & C
Cytochrome-P450 INDEPENDENT oxidation
- amine oxidase
- epoxidation
- N-oxidation
- S-oxidation
- deamination