Anesthesia Pharmacology Chapter 25: Pulmonary Pharmacology Practice Questions

Side effect/effects associated with activation of extrapulmonary ß-adrenergic receptors due to sympathomimetic amines used in treating asthma:
1. Tachycardia
2. Hypokalemia
3. Ventilation-perfusion mismatch
4. A & B
5. B & C
6. A & C
7. A, B & C
Hypokalemia represents a serious side effects secondary to extrapulmonary ß receptor activation.
1. True
2. False
In asthma, repetitive or continuous treatment with a ß adrenergic receptor agonist can result in tolerance secondary to receptor down-regulation (reduced receptor number).
1. True
2. False
Tolerance to which one of the following ß2 receptor associated responses is least likely to occur?
1. Bronchodilator effects of ß2 agonists
2. Cardiovascular responses
3. Metabolic responses
Frequent use of inhaled ß2 adrenergic agonists appears associated with an increased asthma morbidity.
1. True
2. False
Concerning the use of methylxanthines in asthma: which one/ones of the following statements is/are correct?
1. Methylxanthines including theophylline have been employed in asthma treatment for over 70 years.
2. Theophylline has become more useful with the introduction of reliable slow-release formulations.
3. Both
4. Neither
Comparative theophylline pharmacology;choose the correct statement/statements:
1. Theophylline is considered less effective when compared with inhaled ß2 agonists in causing bronchodilation
2. Inhaled corticosteroids exhibit more prominent anti-inflammatory effects compared to theophylline
3. Both
4. Neither
Theophylline appears to exhibit not only a bronchodilator effect but also an anti-inflammatory effect in asthma.
1. True
2. False
IV aminophylline has been used in treatment of acute, severe asthma..
1. True
2. False
Nebulized ß2 adrenergic receptor agonist are considered preferable over IV aminophylline for management of acute worsening of asthma and COPD.
1. True
2. False