Anesthesia Pharmacology Chapter 26: Renal Pharmacology Practice Questions

Example(s) of potassium-sparing diuretic:
1. Triamterene
2. Amiloride
3. Both
4. Neither
Example(s) of potassium-sparing diuretic(s):
1. Eplerenone (Instra)
2. Spirolactone (Aldactone)
3. Both
4. Neither
Mechanism of action (K⁺-sparing diuretic) by means of blocking mineralocorticoid receptors:
1. Triamterene
2. Eplerenone
3. Amiloride
4. None of the above
Mechanism of action of potassium sparing diuretic: inhibition of Na⁺ ion channels (luminal membrane)
1. Amiloride
2. Spirolactone
3. Eplerenone
4. All of the above
Triamterene and amiloride pharmacology:
1. These agents are organic basis, utilizing organic base secretory mechanisms
2. Main site of action: late distal tubules and collecting ducts
3. Both
4. Neither
Amiloride and triamterene block epithelial sodium channels in latest the tubules and collecting ducts through interaction at a binding site in the pore of the channel.
1. True
2. False
Concerning amiloride and triamterene pharmacokinetics:
1. Amiloride exhibits an elimination pathway mainly due to renal excretion of the active agent.
2. Triamterene elimination depends on hepatic metabolism to an active metabolite which is excreted in the urine.
3. Both
4. Neither
Triamterene toxicity:
1. Increased in patients with liver disease
2. Decreased in patients with renal failure
3. Both
4. Neither
The potassium sparing diuretics tram train or amiloride because of their favorable safety profile are often used as monotherapy in management of hypertension or edema.
1. True
2. False
Amiloride and triamterene both increase tubular glomerular feedback and all the renal hemodynamics.
1. True
2. False