Anesthesia Pharmacology:
Serotonin Pharmacology Practice Questions
Choose the correct answer for each question.
Peak plasma concentration of sumatriptan following subcutaneous administration (autoinjector) occurs in about:
- 2 min.
- 6 min.
- 12 min.
- 24 min.
Oral administration of sumatriptan:
- Peak plasma concentration within about 1-2 hours
- Oral bioavailability is about 15%
- Both
- Neither
Newer triptans relative to sumatriptan exhibit higher oral bioavailability..
- True
- False
Some degree of effectiveness in preventing migraine:
- Valproic acid (Depakote)
- Topiramate (Topamax, Qudexy XR, Trokendi XR)
- Both
- Neither
Useful in migraine prophylaxis in some patients:
- Propranolol (Inderal)
- Amitriptyline (Elavil)
- Both
- Neither
Tegaserod (Zelnorm, Zelmac)
- Classified as a 5-HT4
partial agonist.
- Clinical use: irritable bowel syndrome with constipation
- Both
- Neither
Most cases of serotonin syndrome involve high dose of a single serotonergic drug.
- True
- False
Presentation of serotonin syndrome involves/involves:
- Changed mental status e.g. anxiety, confusion, agitated state.
- Abnormal neuromuscular function e.g. clonus, lower extremity rigidity, hyperreflexia.
- Autonomic abnormalities e.g. diaphoresis, hyperthermia, tachycardia, flushing.
- A & B
- B & C
- A & C
- A, B & C
Most indicative clinical finding leading to a diagnosis of serotonin syndrome:
- Mental confusion
- Lower extremity rigidity with clonus is more pronounced compared to upper extremity rigidity.
- Alternating hypotension and hypertension.
- Alternating hypothermia and hyperthermia.
- All of the above findings are equally helpful in the diagnosis of serotonin syndrome.
A diagnosis of serotonin syndrome may be confirmed by one of several laboratory findings.
- True
- False