Medical Pharmacology Chapter 35: Antibacterial Drug Practice Questions

In patients receiving class 1A antiarrhythmic drugs such as procainamide or quinidine or are receiving class 3 antiarrhythmic drugs such as sotalol, amiodarone, or ibutilide, which one(s) of the following agents should not be used or used only cautiously due to potential exacerbation of QTc interval prolongation.
1. Levofloxacin
2. Gemifloxacin
3. Both
4. Neither
Gatifloxacin and moxifloxacin should likely be avoided are used only cautiously in patients with known QTc interval prolongation.
1. True
2. False
In patients receiving drugs which may increase QTc interval, certain fluoroquinolones, which themselves may prolong the QTc, should be avoided or administered only cautiously.
1. True
2. False
Which one/ones of the following adverse effects are considered in the "most prominent" category of adverse effects due to quinolones:
1. Diarrhea
2. Nausea
3. Vomiting
4. A & B
5. B & C
6. A & C
7. A, B & C
All fluoroquinolones except delafloxacin, are likely to lengthen the QT interval.
1. True
2. False
Tendinitis, as well as tendon rupture, may occur associated with quinolone antibiotic administration.
1. True
2. False
Patients who report musculoskeletal-related symptoms while on fluoroquinolones should discontinue treatment, due to the tendinopathy adverse effect noted with quinolone agents.
1. True
2. False
Fluoroquinolones neuropathy:
1. Fluroquinolone administration, either by the intravenous oral route of administration have been associated with central and peripheral neuropathologies.
2. Neurotoxicities associated with fluroquinolone treatment may continue following drug discontinuation and in certain circumstances may be permanent in nature.
3. Both
4. Neither