Medical Pharmacology: Cancer Chemotherapy Drug Practice Questions
Choose the correct answer for each question.
Mechanism of cellular resistance to polyfunctional alkylating drugs:
- decreased DNA repair capability
- reduced production of glutathione
- increased permeability to the drug
- none of the above
Does not have direct vesicant effects:
- mechlorethamine (Mustargen)
- carmustine (BNCU,BiCNU)
- cyclophosphamide (Cytoxan)
- A & B
Polyfunctional alkylating agent used specifically for chronic myeloid leukemia:
- cyclophosphamide (Cytoxan)
- busulfan (Myleran)
- thiopeta (Thioplex)
- dacarbazine (DTIC)
Major toxicity of alkylating drugs:
- alopecia
- myelosuppression
- renal damage
- hepatic failure
Most useful alkylating drug currently available:
- melphalan (Alkeran)
- cyclophosphamide (Cytoxan)
- lomustine (CCNU,CeeNU)
- thiopeta (Thioplex)
Most common route of administration for melphalan (Alkeran):
- oral
- iv
Most common route of administration for cyclophosphamide (Cytoxan):
- iv
- oral
Nitrosourea with minimal bone-marrow suppression and effective in treating pancreatic, islet cell carcinoma.
- lomustine (CCNU,CeeNU)
- carmustine (BNCU,BiCNU)
- streptozocin (Zanosar)
- procarbazine (Matulane)
Used in combination with vinblastine and bleomycin: a major advance in treating nonseminomatous testicular cancer:
- altretamine (Hexalen)
- cisplatin (Platinol)
- procarbazine (Matulane)
- methotrexate
Little effect on the bone marrow: can cause significant renal dysfunction and sometimes acoustic nerve dysfunction.
- methotrexate
- cisplatin (Platinol)
- lomustine (CCNU,CeeNU)
- A & C
Anticancer drug that is also used to treat psoriasis and rheumatoid arthritis:
- mercaptomurine (6-MP)
- methotrexate
- procarbazine (Matulane)
- allopurinol (Zyloprim, Purinol)
Combination of allopurinol with this anticancer drug can cause an increase in toxicity:
- 6-thioguanine
- flurouracil (5-FU)
- 6-mercaptopurine
- azatadine (Optimine)
Recommended for treating hairy cell leukemia
- methotrexate
- cladribine (Leustatin)
- vinblastine (Velban)
- cytarabine (ara-C)
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