Medical Pharmacology: Chemotherapy Practice Questions

Mechanism of cellular resistance to polyfunctional alkylating drugs:
1. decreased DNA repair capability
2. reduced production of glutathione
3. increased permeability to the drug
4. none of the above
Does not have direct vesicant effects:
1. mechlorethamine (Mustargen)
2. carmustine (BNCU,BiCNU)
3. cyclophosphamide (Cytoxan)
4. A & B
Polyfunctional alkylating agent used specifically for chronic myeloid leukemia:
1. cyclophosphamide (Cytoxan)
2. busulfan (Myleran)
3. thiopeta (Thioplex)
4. dacarbazine (DTIC)
Major toxicity of alkylating drugs:
1. alopecia
2. myelosuppression
3. renal damage
4. hepatic failure
Most useful alkylating drug currently available:
1. melphalan (Alkeran)
2. cyclophosphamide (Cytoxan)
3. lomustine (CCNU,CeeNU)
4. thiopeta (Thioplex)
Most common route of administration for melphalan (Alkeran):
1. oral
2. iv
Most common route of administration for cyclophosphamide (Cytoxan):
1. iv
2. oral
Nitrosourea with minimal bone-marrow suppression and effective in treating pancreatic, islet cell carcinoma.
1. lomustine (CCNU,CeeNU)
2. carmustine (BNCU,BiCNU)
3. streptozocin (Zanosar)
4. procarbazine (Matulane)
Used in combination with vinblastine and bleomycin: a major advance in treating nonseminomatous testicular cancer:
1. altretamine (Hexalen)
2. cisplatin (Platinol)
3. procarbazine (Matulane)
4. methotrexate
Little effect on the bone marrow: can cause significant renal dysfunction and sometimes acoustic nerve dysfunction.
1. methotrexate
2. cisplatin (Platinol)
3. lomustine (CCNU,CeeNU)
4. A & C
Anticancer drug that is also used to treat psoriasis and rheumatoid arthritis:
1. mercaptomurine (6-MP)
2. methotrexate
3. procarbazine (Matulane)
4. allopurinol (Zyloprim, Purinol)
Combination of allopurinol with this anticancer drug can cause an increase in toxicity:
1. 6-thioguanine
2. flurouracil (5-FU)
3. 6-mercaptopurine
4. azatadine (Optimine)
Recommended for treating hairy cell leukemia
1. methotrexate
2. cladribine (Leustatin)
3. vinblastine (Velban)
4. cytarabine (ara-C)