Medical Pharmacology: Chemotherapy Practice Questions

Mechanism(s) of action for anthracycline anticancer agents:
1. blockade of DNA and RNA synthesis
2. alteration of membrane fluidity
3. generation of oxygen free radicals
4. all of the above
Major clinical use of this antracycline anticancer, antibiotic is in treatment of acute leukemia.
1. dactinomycin (Cosmegen)
2. bleomycin (Blenoxane)
3. daunorubicin (DaunoXome)
4. doxorubicin (Adriamycin)
Among anticancer antibiotics: most toxic--
1. plicamycin (Mithramycin)
2. dactinomycin (Cosmegen)
3. doxorubicin (Adriamycin)
4. bleomycin (Blenoxane)
Antibiotic anticancer drug that is bioactivated to an alkylating agent. Hypoxic solid tumor stem cells may be most susceptible.
1. doxorubicin (Adriamycin)
2. mitomycin (Mutamycin)
3. vincristine (Oncovin)
4. plicamycin (Mithramycin)
Anthracycline analog useful in treating acute myeloid leukemia; In combination with cytarabine (ARA-C), it can produce complete remissions in patients with acute myelogenous leukemia.
1. plicamycin (Mithramycin)
2. idarubicin (Idamycin)
3. bleomycin (Blenoxane)
4. paclitaxel (Taxol)
Anticancer drug: acts on osteoclasts to decrease serum calcium levels (independent of its antitumor action)
1. dactinomycin (Cosmegen)
2. doxorubicin (Adriamycin)
3. bleomycin (Blenoxane)
4. plicamycin (Mithramycin)